4-Amino-L-phenylalanine
Based on 1 Customer Validation
4-Amino-L-phenylalanine (H-Phe(4-NH2)-OH) is a metabolic intermediate and an α-carbonic anhydrase (TcCA) activator with a Ka value of 0.75 μM. 4-Amino-L-phenylalanine acts through active site cavity entrance binding and a proton shuttle mechanism to enhance the catalytic rate of CO2 hydration. 4-Amino-L-phenylalanine serves as a diamine monomer for bio-based polymer synthesis and is produced in Escherichia coli via the shikimate pathway. 4-Amino-L-phenylalanine constitutes a structural component of haptens used in immunoassay development. 4-Amino-L-phenylalanine is used for the production of Chloramphenicol (HY-B0239) and Pristinamycin I in Streptomyces venezuelae and S. pristinaespiralis, respectively. 4-Amino-L-phenylalanine is used in research related to Trypanosoma cruzi infection.
For research use only. We do not sell to patients.
- Purity : 99.98%
- CAS No.: 943-80-6
- Formula: C9H12N2O2
- Molecular Weight:180.21
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
|
Human Endogenous Metabolite |
In Vitro
4-Amino-L-phenylalanine production in recombinant Escherichia coli HKE6027 is increased to 4.1 g/L (40 g/L glucose; 78 h) by knocking out the ldh gene[1].
4-Amino-L-phenylalanine is produced at 7.4 g/L with glucose as the substrate and 5.7 g/L with sorghum bagasse enzymatic hydrolysate as the substrate in the culture of recombinant Escherichia coli HKE6027, with a yield based on the enzymatic hydrolysate that is 24% lower[1].
4-Amino-L-phenylalanine synthesis in Escherichia coli HKE6027 is inhibited by hydroxybenzaldehydes and cinnamic acid derivatives, both with an IC50 of 20 mg/L, whereas furan aldehydes exhibit only limited inhibition at a concentration of 640 mg/L[1].
4-Amino-L-phenylalanine (15 min pre-incubation, 10 s assay) strongly activates Trypanosoma cruzi α-carbonic anhydrase (TcCA) with a Ka of 0.75 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 943-80-6
-
Appearance Solid
-
Molecular Weight 180.21
-
Formula C9H12N2O2
-
Color White to off-white
-
SMILES
N[C@@H](CC1=CC=C(N)C=C1)C(O)=O
-
Synonyms
H-Phe(4-NH2)-OH
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
H2O : 20 mg/mL (110.98 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 10 mg/mL (55.49 mM); Clear solution; Need ultrasonic
Purity & Documentation
-
Data Sheet (280 KB)
-
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.5491 mL | 27.7454 mL | 55.4908 mL | 138.7270 mL |
| 5 mM | 1.1098 mL | 5.5491 mL | 11.0982 mL | 27.7454 mL | |
| 10 mM | 0.5549 mL | 2.7745 mL | 5.5491 mL | 13.8727 mL | |
| 15 mM | 0.3699 mL | 1.8497 mL | 3.6994 mL | 9.2485 mL | |
| 20 mM | 0.2775 mL | 1.3873 mL | 2.7745 mL | 6.9364 mL | |
| 25 mM | 0.2220 mL | 1.1098 mL | 2.2196 mL | 5.5491 mL | |
| 30 mM | 0.1850 mL | 0.9248 mL | 1.8497 mL | 4.6242 mL | |
| 40 mM | 0.1387 mL | 0.6936 mL | 1.3873 mL | 3.4682 mL | |
| 50 mM | 0.1110 mL | 0.5549 mL | 1.1098 mL | 2.7745 mL | |
| 60 mM | 0.0925 mL | 0.4624 mL | 0.9248 mL | 2.3121 mL | |
| 80 mM | 0.0694 mL | 0.3468 mL | 0.6936 mL | 1.7341 mL | |
| 100 mM | 0.0555 mL | 0.2775 mL | 0.5549 mL | 1.3873 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
4-Amino-L-phenylalanine Related Classifications
HY-W016480 Related Classifications
Powered by Bioz