2. Disease Areas
  3. Infection
  4. Parasitic Infection
  5. Trypanosome Infection

Trypanosome Infection

Trypanosome infection is caused by parasites of the genus Trypanosoma, which are heteroxenous trypanosomatids with complex life cycles involving multiple hosts. Notable species include Trypanosoma cruzi, responsible for Chagas' disease, and Trypanosoma brucei, which causes African sleeping sickness. Recent molecular evidence, particularly from 18S rRNA analyses, supports the monophyly of the genus and suggests that nearly half of the genetic diversity within trypanosomatids resides in Trypanosoma, although this may reflect sampling bias. Some species, such as T. cruzi and T. congolense, exhibit genetic diversity comparable to entire well-studied genera like Leishmania. The genus comprises several distinct monophyletic clades, including the 'T. brucei', 'T. cruzi', and 'Aquatics' groups, which may inform a future taxonomic revision of the genus.

References:

Trypanosome Infection (29):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W540326
    Norbornane 279-23-2 98.86%
    Norbornane is a component of the essential oil extracted from the rhizomes of Cyperus rotundus from Morocco. Active derivatives of Norbornane are fused heterocyclic compounds with in vitro anti-tumor and anti-Trypanosoma brucei activities. Norbornane and its derivatives can be used in research related to cancers such as leukemia and African trypanosomiasis.
    Norbornane
  • HY-N11173A
    trans-Melilotoside 618-67-7 99.79%
    trans-Melilotoside is a coumarin precursor and that can be isolated from Melilotus neapolitan. trans-Melilotoside exhibits antiparasitic and DPPH radical-scavenging activity. trans-Melilotoside can be used for the research of human african trypanosomiasis, chagas’ disease, malaria[1][3].
    trans-Melilotoside
  • HY-N6674
    Diazepinomicin 733035-26-2 98.04%
    Diazepinomicin (ECO-4601) is an anticancer and antibacterial agent. Diazepinomicin can be produced by a Micromonospora strain. Diazepinomicin induces Apoptosis. Diazepinomicin inhibits the proteases Rhodesain and Cathepsin L at an IC50 of 70-90 μM. Diazepinomicin possesses anti-inflammatory and anti-tumor activity. Diazepinomicin has demonstrated activity against hepatocellular carcinoma. Diazepinomicin shows antiparasitic activity against trypomastigote forms of Trypanosoma brucei with an IC50 of 13.5 μM. Diazepinomicin exhibits moderate antibacterial activity against specific Gram-positive bacteria, with an MIC of approximately 32 μg/mL.
    Diazepinomicin
  • HY-118965
    Alazopeptin 1397-84-8
    Alazopeptin is a non-ribosomal tripeptide azoamino acid antibiotic isolated from various Streptomyces species, with significant anti-tumor, antibacterial and trypanocidal activities. Alazopeptin exhibits cytotoxicity against mouse leukemia cells and S-180 tumor cells, inhibits the growth of Bacillus subtilis, and shows activity against Trypanosoma brucei. Alazopeptin can be widely used in studies related to mouse leukemia, S-180 tumor, human African trypanosomiasis and nagana.
    Alazopeptin
  • HY-183747
    Antitrypanosomal agent 32 1916476-01-1
    Antitrypanosomal agent 32 is a antitrypanosomal agent with nanomolar potency against multiple Trypanosoma cruzi strains, including CL-Brener, Y, Dm28c-Luc and Tulahuen. Antitrypanosomal agent 32 sustains inhibition of parasite growth after washing and reduces parasitemia levels in BALB/c mice. Antitrypanosomal agent 32 can be used for the research of trypanosome infection.
    Antitrypanosomal agent 32
  • HY-N19727
    Chamissonolide 78853-98-2
    Chamissonolide is a sesquiterpene lactone with cytotoxic, anti-inflammatory and trypanocidal activities. Chamissonolide reduces the mRNA levels of IL-2, IFN-γ, GM-CSF, iNOS and TNF-α, and upregulates the mRNA level of NF-ATc. Chamissonolide decreases the population of naturally occurring apoptotic cells. Chamissonolide can be used in research related to tumors, African trypanosomiasis and Chagas disease.
    Chamissonolide
  • HY-Z15986
    Methotrexate diethyl ester 43170-88-3
    Methotrexate diethyl ester is a potent DHFR inhibitor. Methotrexate diethyl ester can be used in the research of T.cruzi infection and leukemia.
    Methotrexate diethyl ester
  • HY-184202
    Antitrypanosomal agent 33
    Antitrypanosomal agent 33 is a potent antitrypanosomal agent with activity against Trypanosoma cruzi intracellular amastigotes, Trypanosoma brucei brucei, and Trypanosoma brucei rhodesiense. Antitrypanosomal agent 33 can be used for the research of trypanosomiasis, chagas disease.
    Antitrypanosomal agent 33
  • HY-N19754
    Cladospirone B 307503-97-5
    Cladospirone B is a secondary metabolite of the endophytic fungus Lasiodiplodia theobromae. Cladospirone B exhibits trypanocidal activity, with a MIC of 17.8 µM against Trypanosoma brucei. Cladospirone B can be used in the research of African human trypanosomiasis (sleeping sickness).
    Cladospirone B
  • HY-180418
    Homidium chloride 602-52-8
    Homidium chloride is a potent antiparasitic agent exhibiting activity against Trypanosoma rhodesiense and Trypanosoma congolense. Homidium chloride can reduce parasitaemia in murine models of infection. Homidium chloride can be used for trypanosomiasis research.
    Homidium chloride
  • HY-W743767
    Mizoribine 5'-monophosphate 62025-48-3
    Mizoribine 5'-monophosphate (MZR-P) is the active metabolite of Mizoribine (HY-17470). Mizoribine 5'-monophosphate is an inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), and its Ki values for IMPDH of Trypanosoma brucei, Bacillus subtilis and Oceanobacillus iheyensis are 3.3, 72 and 157 nM respectively. Mizoribine 5'-monophosphate can be used in anti-trypanosomiasis and immunosuppression research.
    Mizoribine 5'-monophosphate
  • HY-112252
    MDL 73811 123642-27-3
    MDL 73811 is a potent AdoMetDC inhibitor and anti-trypanosomal compound. MDL 73811 has curative efficacy in a hemolymphatic model of HAT.
    MDL 73811
  • HY-169728
    SID 24785302 378197-09-2
    SID 24785302 is a hexokinase inhibitor with antiparasitic activity. SID 24785302 exhibits activity against T. brucei and Leishmania. SID 24785302 can be used for the research of mitochondrial DNA disorders and parasitic infection.
    SID 24785302
  • HY-112453
    IMDNQ1 623163-52-0
    IMDNQ1 is a Trypanosoma cruzi inhibitor derived from 1,4-naphthoquinone substituted with cyclic imide. IMDNQ1 effectively inhibits the proliferation of Trypanosoma cruzi epimastigotes, while also reducing the viability of mouse fibroblasts. The selectivity index between the antiproliferative activity and cytotoxicity of IMDNQ1 is 60.25, indicating a certain level of safety. IMDNQ1 can be widely used in studies related to Chagas disease.
    IMDNQ1
  • HY-183529
    Antitrypanosomal agent 31 551919-54-1
    Antitrypanosomal agent 31 is an antitrypanosoma agent with a pEC50 of 6.4. Antitrypanosomal agent 31 inhibits GSK-3β, CDK-2, and CDK-4 with pIC50s of 5.8, 6.9, and 7.1, respectively. Antitrypanosomal agent 31 can be used for the research of human african trypanosomiasis.
    Antitrypanosomal agent 31
  • HY-182516
    Aminobutane bisphosphonate 32545-60-1
    Aminobutane bisphosphonate is a Trypanosoma cruzi farnesyl pyrophosphate synthase (FPPS) inhibitor with an IC50 of 30.77 μM against Trypanosoma cruzi. Aminobutane bisphosphonate inhibits proliferation of intracellular amastigote Trypanosoma cruzi and lacks activity against non-infective epimastigote forms. Aminobutane bisphosphonate reduces osteoclastic bone resorption, osteoid surface extent, and osteoclast number per mm of bone surface. Aminobutane bisphosphonate can be used for the research of american trypanosomiasis (chagas' disease) and immobilization-related bone loss.
    Aminobutane bisphosphonate
  • HY-125188
    NEU-4438 2306305-57-5
    NEU-4438 is an antimalarial agent. NEU-4438 inhibits DNA synthesis, reduces AMPK-γ, and increases Clathrin heavy chain. NEU-4438 exhibits antiparasitic activity against Trypanosoma brucei. NEU-4438 reduces trypanosome tissue burden in a chronic HAT mouse model.
    NEU-4438
  • HY-N18878
    Ambigol C 850655-31-1
    Ambigol C is an ambigol, Antibacterial agent and Antimalarial agent. Ambigol C is isolated from Fischerella ambigua 108b. Ambigol C exhibits selective antibacterial activity against Gram-positive Staphylococcus aureus strains (including MRSA) with MIC values of 0.98-3.91 μg/mL. Ambigol C also shows potent antibacterial activity against B. megaterium, and possesses weak antimalarial and trypanocidal effects. Ambigol C can be used in the research of bacterial infections, plasmodial infections and trypanosomal infections.
    Ambigol C
  • HY-185309
    Anti-Trypanosoma cruzi agent-9 3094993-05-9
    Anti-Trypanosoma cruzi agent-9 is a topoisomerase II inhibitor. Anti-Trypanosoma cruzi agent-9 inhibits the growth of Trypanosoma cruzi and Leishmania donovani.
    Anti-Trypanosoma cruzi agent-9
  • HY-148014
    TH7299 1415648-20-2
    TH7299 is a TbFolD inhibitor with antiparasitic activity. TH7299 binds the tetrahydrofolate-binding pocket of MTHFD2, and inhibits MTHFD2L and the dehydrogenase/cyclohydrolase domain of MTHFD1. TH7299 reduces cancer cells viability, induces apoptosis, DNA damage. TH7299 can be used for the researches of african trypanosomiasis and acute myeloid leukemia.
    TH7299