Antitrypanosomal agent 32 

Antitrypanosomal agent 32 is a antitrypanosomal agent with nanomolar potency against multiple Trypanosoma cruzi strains, including CL-Brener, Y, Dm28c-Luc and Tulahuen. Antitrypanosomal agent 32 sustains inhibition of parasite growth after washing and reduces parasitemia levels in BALB/c mice. Antitrypanosomal agent 32 can be used for the research of trypanosome infection^[1].

Antitrypanosomal agent 32 (compound 2) inhibits Trypanosoma cruzi Tulahuen strain intracellular amastigotes in L929 cells with an IC₅₀ of 5.4 μM and has a selectivity index of 46 relative to L929 cell cytotoxicity^[1].
Antitrypanosomal agent 32 inhibits Trypanosoma cruzi Dm28c-Luc strain intracellular amastigotes in Vero cells with an IC₅₀ of 4.9 μM and IC₉₀ of 36 μM, with selectivity indexes >61 and >8 respectively due to no detected cytotoxicity in Vero cells^[1].
Antitrypanosomal agent 32 inhibits Trypanosoma cruzi Y strain intracellular amastigotes in L6 cells with an IC₅₀ of 0.16 μM and has a selectivity index of >1875 relative to L6 cell cytotoxicity^[1].
Antitrypanosomal agent 32 inhibits Trypanosoma cruzi CL-Brener-Luc strain intracellular amastigotes in L6 cells with an IC₅₀ of 0.036 μM and IC₉₀ of 0.094 μM, with selectivity indexes >8333 and >3191 respectively due to no detected cytotoxicity in L6 cells^[1].
Antitrypanosomal agent 32 (36-125 μM; 3 days post-washout) exhibits trypanocidal activity against Trypanosoma cruzi Dm28c-Luc strain in Vero cells, with 92.6% and 95.2% growth inhibition 3 days after washout from IC₉₀ (36 μM) and 125 μM exposures respectively^[1].
Antitrypanosomal agent 32 (0.094-1 μM; 10 days post-washout) exhibits trypanocidal activity against Trypanosoma cruzi CL-Brener-Luc strain in L6 cells, with 89.4% and 99.6% growth inhibition 10 days after washout from IC₉₀ (0.094 μM) and 1 μM exposures respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitrypanosomal agent 32 (compound 2) (10-50 mg/kg; i.p.; daily; 10 days) achieves an 84% maximum reduction in parasitemia in female BALB/c mice with acute Chagas disease, with no observed acute toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

317.41

C₁₆H₁₉N₃O₂S

1916476-01-1

O=C(N1CCOCC1)NCCC2=NC(C3=CC=CC=C3)=CS2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Dit Lapierre TJWJ, et al. Discovery of an efficacious 2-ethyl-4-phenylthiazole derivative against acute Chagas disease via multiparametric hit-to-lead optimization and in vivo efficacy. Eur J Med Chem. 2026;313:118888.