IMDNQ1
IMDNQ1 is a Trypanosoma cruzi inhibitor derived from 1,4-naphthoquinone substituted with cyclic imide. IMDNQ1 effectively inhibits the proliferation of Trypanosoma cruzi epimastigotes, while also reducing the viability of mouse fibroblasts. The selectivity index between the antiproliferative activity and cytotoxicity of IMDNQ1 is 60.25, indicating a certain level of safety. IMDNQ1 can be widely used in studies related to Chagas disease.
For research use only. We do not sell to patients.
- CAS No.: 623163-52-0
- Formula: C14H8ClNO4
- Molecular Weight:289.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
IMDNQ1 (0.39-100 μM; 48 h) exhibits low cytotoxicity to Balb/C 3T3 mouse fibroblasts with an IC50 of 165.9 μM, resulting in a selectivity index of 60.25 that is significantly higher than Nifurtimox (HY-W040073)[1].
IMDNQ1 (0.39-100 µM; 48 h) potently inhibits the proliferation of Trypanosoma cruzi epimastigotes (Tulahuen CL98 strain) with an IC50 of 2.77 µM, showing significantly greater activity than Nifurtimox (HY-W040073)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Balb/C 3T3 mouse fibroblasts (clone A31)
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Concentration:0.39-100 µM
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Incubation Time:48 h
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Result:Reduced the viability of Balb/C 3T3 mouse fibroblasts with an IC50 of 165.9 µM.
Exhibited significantly less cytotoxicity than nifurtimox (IC50=114.0 µM).
Achieved a selectivity index of 60.25, which is significantly higher than the selectivity index of nifurtimox.
Chemical Information
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CAS No. 623163-52-0
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Molecular Weight 289.67
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Formula C14H8ClNO4
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SMILES
O=C1C(Cl)=C(C(=O)C=2C=CC=CC12)N3C(=O)CCC3=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IMDNQ1 Related Classifications
HY-112453 Related Classifications
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