2. Anti-infection
  3. Parasite
  4. IMDNQ1

IMDNQ1 is a Trypanosoma cruzi inhibitor derived from 1,4-naphthoquinone substituted with cyclic imide. IMDNQ1 effectively inhibits the proliferation of Trypanosoma cruzi epimastigotes, while also reducing the viability of mouse fibroblasts. The selectivity index between the antiproliferative activity and cytotoxicity of IMDNQ1 is 60.25, indicating a certain level of safety. IMDNQ1 can be widely used in studies related to Chagas disease.

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IMDNQ1

IMDNQ1 Chemical Structure

CAS No. : 623163-52-0

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IMDNQ1 Related Antibodies

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Description

IMDNQ1 is a Trypanosoma cruzi inhibitor derived from 1,4-naphthoquinone substituted with cyclic imide. IMDNQ1 effectively inhibits the proliferation of Trypanosoma cruzi epimastigotes, while also reducing the viability of mouse fibroblasts. The selectivity index between the antiproliferative activity and cytotoxicity of IMDNQ1 is 60.25, indicating a certain level of safety. IMDNQ1 can be widely used in studies related to Chagas disease[1][2].

In Vitro

IMDNQ1 (0.39-100 μM; 48 h) exhibits low cytotoxicity to Balb/C 3T3 mouse fibroblasts with an IC50 of 165.9 μM, resulting in a selectivity index of 60.25 that is significantly higher than Nifurtimox (HY-W040073)[1].
IMDNQ1 (0.39-100 µM; 48 h) potently inhibits the proliferation of Trypanosoma cruzi epimastigotes (Tulahuen CL98 strain) with an IC50 of 2.77 µM, showing significantly greater activity than Nifurtimox (HY-W040073)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IMDNQ1 Related Antibodies

Cell Cytotoxicity Assay[2]

Cell Line: Balb/C 3T3 mouse fibroblasts (clone A31)
Concentration: 0.39-100 µM
Incubation Time: 48 h
Result: Reduced the viability of Balb/C 3T3 mouse fibroblasts with an IC50 of 165.9 µM.
Exhibited significantly less cytotoxicity than nifurtimox (IC50=114.0 µM).
Achieved a selectivity index of 60.25, which is significantly higher than the selectivity index of nifurtimox.
Molecular Weight

289.67

Formula

C14H8ClNO4
CAS No.
SMILES

O=C1C(Cl)=C(C(=O)C=2C=CC=CC12)N3C(=O)CCC3=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IMDNQ1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IMDNQ1623163-52-0IMDNQ 1IMDNQ-1ParasiteTrypanosoma cruziBalb/C 3T3 mouse fibroblastschagas diseasefibroblast cytotoxicitymouse fibroblast cellsTulahuen CL98 strainepimastigotesantiproliferative activityInhibitorinhibitorinhibit

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