Norbornane 

Norbornane is a component of the essential oil extracted from the rhizomes of Cyperus rotundus from Morocco. Active derivatives of Norbornane are fused heterocyclic compounds with in vitro anti-tumor and anti-Trypanosoma brucei activities. Norbornane and its derivatives can be used in research related to cancers such as leukemia and African trypanosomiasis^[1][2].

Norbornane accounts for 0.09% of the essential oil extracted from the rhizomes of Cyperus rotundus L. from Morocco, and this result is confirmed by GC-MS analysis^[1].
Norbornane-fused thiopyranothiazole active derivatives selectively restrain leukemia cells and completely inhibit colon cancer cell proliferation, while related analogs suppress Trypanosoma brucei. These derivatives bind targets via hydrophobic interactions and induce tumor cell cycle arrest and apoptosis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

96.17

C₇H₁₂

279-23-2

Solid

White to off-white

C12CCC(C2)CC1

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Siroua K, et al. Chemical composition of essential oil from invasive Moroccan Cyperus rotundus L., in vitro antimicrobial and antiradical activities, and in silico molecular docking of major compounds on drug efflux pumps. South African Journal of Botany. 2022;147:782-789.

  [2]. Kryshchyshyn AP, et al. Investigation of anticancer and anti-parasitic activity of thiopyrano[2,3-d]thiazoles bearing norbornane moiety. Bioorganic Chemistry. 2017;33:183-205.