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  4. Homidium chloride

Homidium chloride is a potent antiparasitic agent exhibiting activity against Trypanosoma rhodesiense and Trypanosoma congolense. Homidium chloride can reduce parasitaemia in murine models of infection. Homidium chloride can be used for trypanosomiasis research.

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Homidium chloride

Homidium chloride Chemical Structure

CAS No. : 602-52-8

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Homidium chloride Related Antibodies

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Description

Homidium chloride is a potent antiparasitic agent exhibiting activity against Trypanosoma rhodesiense and Trypanosoma congolense. Homidium chloride can reduce parasitaemia in murine models of infection. Homidium chloride can be used for trypanosomiasis research[1][2].

In Vitro

Homidium chloride (0.001-10 μg/mL; 6 h) eliminates the infectivity of T. congolense in vitro in citrate-saline at ≥ 0.1 μg/mL, but not in horse serum[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Homidium chloride Related Antibodies
In Vivo

Homidium (0.075-75.0 mg/kg; i.p., single dose) chloride exhibits antitrypanosomal activity against T. rhodesiense and T. congolense in the infectivity suppression mouse model, showing greater potency against T. rhodesiense[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice infected with T. rhodesiense and T. congolense[1]
Dosage: 75.0, 7.5, 0.75, 0.075 mg/kg
Administration: i.p.; single dose
Result: Exhibited antitrypanosomal activity against both T. rhodesiense and T. congolense.
Was approximately 12.5 times more active against T. congolense compared to T. rhodesiense.
Molecular Weight

349.86

Formula

C21H20ClN3
CAS No.
SMILES

NC1=CC2=C(C3=C([N+](CC)=C2C4=CC=CC=C4)C=C(N)C=C3)C=C1.[Cl-]
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Homidium chloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Homidium602-52-8ParasitetrypanosomiasisTrypanosoma congolenseTrypanosoma rhodesienselivestocktrypanosome inhibitorgoatstrypanosome infectionscalvesphenanthridinium trypanocidemiceInhibitorinhibitorinhibit

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