SID 24785302
SID 24785302 is a hexokinase inhibitor with antiparasitic activity. SID 24785302 exhibits activity against T. brucei and Leishmania. SID 24785302 can be used for the research of mitochondrial DNA disorders and parasitic infection.
For research use only. We do not sell to patients.
- CAS No.: 378197-09-2
- Formula: C14H12N2O3S2
- Molecular Weight:320.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
SID 24785302 (10 μM; 2 h) potently and selectively inhibits bacterially expressed Trypanosoma brucei hexokinase 1 with an IC50 of 4.2 μM, while causing minimal inhibition of human glucokinase at 10 μM[3].
SID 24785302 (3 days) potently inhibits the growth of Trypanosoma brucei bloodstream form parasites with an EC50 of 0.042 μM[3].
SID 24785302 (10 μM; 2 days) moderately inhibits the growth of Trypanosoma brucei procyclic form parasites, causing 47% inhibition at 10 μM[3].
SID 24785302 (44 h) inhibits the growth of Leishmania major promastigotes with an EC50 of 1.9 μM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 378197-09-2
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Molecular Weight 320.39
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Formula C14H12N2O3S2
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SMILES
O=C(CC1=CSC(N2SC3=C(C2=O)C=CC=C3)=N1)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Antonella SPINAZZOLA, et al. Compounds for treating mitochondrial dna disorders. WO2023089313A1.
[2]. Heneberg P. Redox Regulation of Hexokinases. Antioxid Redox Signal. 2019 Jan 20;30(3):415-442. [Content Brief]
[3]. Sharlow ER, et al. A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity. PLoS Negl Trop Dis. 2010;4(4):e659. Published 2010 Apr 13. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SID 24785302 Related Classifications
HY-169728 Related Classifications
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- SID 24785302
- 378197-09-2
- SID24785302
- SID-24785302
- Hexokinase
- Parasite
- mitochondrial DNA disorders
- hexokinase inhibitor
- T. brucei blood stage parasites
- Trypanosoma brucei procyclic form (29-13)
- CYP2D6
- Trypanosoma brucei bloodstream form (90-13)
- Leishmania promastigotes
- Trypanosoma brucei hexokinase 1
- human african trypanosomiasis
- Leishmania major promastigotes
- Inhibitor
- inhibitor
- inhibit