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Cat. No.: HY-N6674

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Diazepinomicin

Name: Diazepinomicin
Brand: MedChemExpress
SKU: HY-N6674
Availability: PreOrder

(Synonyms: ECO-4601; TLN-4601; BU 4664L)

Diazepinomicin (ECO-4601) is an anticancer and antibacterial agent. Diazepinomicin can be produced by a Micromonospora strain. Diazepinomicin induces Apoptosis. Diazepinomicin inhibits the proteases Rhodesain and Cathepsin L at an IC₅₀ of 70-90 μM. Diazepinomicin possesses anti-inflammatory and anti-tumor activity. Diazepinomicin has demonstrated activity against hepatocellular carcinoma. Diazepinomicin shows antiparasitic activity against trypomastigote forms of Trypanosoma brucei with an IC₅₀ of 13.5 μM. Diazepinomicin exhibits moderate antibacterial activity against specific Gram-positive bacteria, with an MIC of approximately 32 μg/mL.

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CAS No.: 733035-26-2
화학식: C₂₈H₃₄N₂O₄
분자량:462.58

보관:

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Diazepinomicin Chemical Structure

CAS No.: 733035-26-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Clinical Trial
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

IC₅₀ & Target^[1]

Microbial Metabolite

Trypanosoma

cathepsin L

70-90 μM (IC₅₀)

All Cathepsin Isoforms :

All Parasite Isoforms :

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HUVEC	IC₅₀	0.43 μg/mL Compound: 1, BU-4664L	Antiinvasive activity against HUVEC assessed as inhibition of cell migration after 6 hrs by Matrigel assay Antiinvasive activity against HUVEC assessed as inhibition of cell migration after 6 hrs by Matrigel assay	[PMID: 20056543]
HUVEC	IC₅₀	0.72 μg/mL Compound: 1, BU-4664L	Antiangiogenic activity against HUVEC cells assessed as inhibition of vascular formation after 6 hrs by wound healing assay Antiangiogenic activity against HUVEC cells assessed as inhibition of vascular formation after 6 hrs by wound healing assay	[PMID: 20056543]
HUVEC	IC₅₀	2 μg/mL Compound: 1, BU-4664L	Cytotoxicity against HUVEC cells Cytotoxicity against HUVEC cells	[PMID: 20056543]
NCI-H460	GI₅₀	13.6 μM Compound: 1; BU-4664L	Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition by MTT assay	[PMID: 34838651]
PC-3	GI₅₀	1.95 μM Compound: 1; BU-4664L	Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition by MTT assay Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition by MTT assay	[PMID: 34838651]
Renca	IC₅₀	0.78 μg/mL Compound: 1, BU-4664L	Antiinvasive activity against mouse Renca by Matrigel assay Antiinvasive activity against mouse Renca by Matrigel assay	[PMID: 20056543]
Renca	IC₅₀	8.3 μg/mL Compound: 1, BU-4664L	Cytotoxicity against mouse Renca cells Cytotoxicity against mouse Renca cells	[PMID: 20056543]

In Vitro

Diazepinomicin (1-25 μM; 24-72 h) induces dose-dependent antiproliferative activity in hepatocellular carcinoma HepG2 cells^[1].
Diazepinomicin exhibits moderate antibacterial activity against specific Gram-positive bacteria, with an MIC of approximately 32 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

human hepatoma HepG2 cells
Concentration:

10-15 μM
Incubation Time:

24 h
Result:

Induced clumping of cells with slight distortion, as well as very condensed and fragmented nuclei (hallmark features of apoptosis). Induced condensed nuclei and apoptotic bodies, characteristic of apoptotic cells. Induced DNA fragmentation, visualized as characteristic DNA ladder bands on agarose gel electrophoresis.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 733035-26-2
Appearance Solid
분자량 462.58
화학식 C₂₈H₃₄N₂O₄
Color Off-white to gray
SMILES

O=C1C2=CC=CC(O)=C2NC3=C(O)C=C(O)C=C3N1C/C=C(C)/CC/C=C(C)/CC/C=C(C)\C
Synonyms

ECO-4601; TLN-4601; BU 4664L
선적

Room temperature in continental US; may vary elsewhere.
보관

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rambabu V, et al. In vitro cytotoxicity perspective of diazepinomicin (ECO-4601) on human hepatoma cell line (HEPG2)[J]. Biomedicine & Aging Pathology, 2014, 4(1): 65-70.

[2]. Charan RD, et al. Diazepinomicin, a new antimicrobial alkaloid from a marine Micromonospora sp. J Nat Prod. 2004;67(8):1431-1433. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Clinical Trial
Chemical Information
순도&문서
References

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Diazepinomicin

Salirasib

Oncrasin-1

ARS-853

Kobe0065

(Rac)-Antineoplaston A10

Salirasib (Standard)

Ras Inhibitory Peptide

All Cathepsin Isoforms

All Parasite Isoforms

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

Diazepinomicin

Salirasib

Oncrasin-1

ARS-853

Kobe0065

(Rac)-Antineoplaston A10

Salirasib (Standard)

Ras Inhibitory Peptide

All Cathepsin Isoforms

All Parasite Isoforms

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Diazepinomicin Related Classifications

HY-N6674 Related Classifications

Bioz