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Cat. No.: HY-N18878

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Ambigol C

Ambigol C is an ambigol, Antibacterial agent and Antimalarial agent. Ambigol C is isolated from Fischerella ambigua 108b. Ambigol C exhibits selective antibacterial activity against Gram-positive Staphylococcus aureus strains (including MRSA) with MIC values of 0.98-3.91 μg/mL. Ambigol C also shows potent antibacterial activity against B. megaterium, and possesses weak antimalarial and trypanocidal effects. Ambigol C can be used in the research of bacterial infections, plasmodial infections and trypanosomal infections.

For research use only. We do not sell to patients.

CAS No.: 850655-31-1
Formula: C₁₈H₈Cl₆O₃
Molecular Weight:484.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ambigol C Chemical Structure

CAS No.: 850655-31-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Microbial Metabolite

Trypanosoma

Plasmodium

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Cellular Effect

Cell Line	Type	Value	Description	References
L6	MIC	100 μg/mL Compound: 1, ambigol C	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 15787461]

In Vitro

Ambigol C (24 h for antibacterial/antimycotic, 48 h for cytotoxicity) displays selective antibacterial activity against Gram-positive Staphylococcus aureus strains (including MRSA) with MIC values of 0.98-3.91 μg/mL, no activity against Escherichia coli or Candida albicans, and an IC₅₀ of 40 μg/mL against MRC-5 human lung fibroblasts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 850655-31-1
Molecular Weight 484.97
Formula C₁₈H₈Cl₆O₃
SMILES

ClC1=CC=C(C(Cl)=C1)OC2=C(Cl)C(O)=C(Cl)C(OC3=CC=C(C=C3Cl)Cl)=C2
Structure Classification
- Phenols
- Monophenols
Initial Source
- Microorganisms
Fischerella ambigua
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Milzarek TM, et al. Antibiotic Potential of the Ambigol Cyanobacterial Natural Product Class and Simplified Synthetic Analogs. ACS Infect Dis. 2023;9(10):1941-1948. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Ambigol C

All Endogenous Metabolite Isoforms

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Ambigol C Related Classifications

HY-N18878 Related Classifications