2. Anti-infection
  3. Parasite
  4. Antitrypanosomal agent 33

Antitrypanosomal agent 33 is a potent antitrypanosomal agent with activity against Trypanosoma cruzi intracellular amastigotes, Trypanosoma brucei brucei, and Trypanosoma brucei rhodesiense. Antitrypanosomal agent 33 can be used for the research of trypanosomiasis, chagas disease.

For research use only. We do not sell to patients.

Antitrypanosomal agent 33

Antitrypanosomal agent 33 Chemical Structure

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Antitrypanosomal agent 33 Related Antibodies

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Description

Antitrypanosomal agent 33 is a potent antitrypanosomal agent with activity against Trypanosoma cruzi intracellular amastigotes, Trypanosoma brucei brucei, and Trypanosoma brucei rhodesiense. Antitrypanosomal agent 33 can be used for the research of trypanosomiasis, chagas disease[1].

In Vitro

Antitrypanosomal agent 33 (compound 1) potently inhibits T. cruzi, T. b. brucei, and T. b. rhodesiense with IC50 values of 0.23, 0.59, and 0.81 μM, respectively[1].
Antitrypanosomal agent 33 shows low cytotoxicity in MRC-5 cells, with a CC50>61 μM[1].
Antitrypanosomal agent 33 (100 μM) is a substrate for Trypanosoma cruzi type I nitroreductase, with an observed rate constant of 0.11/s[1].
Antitrypanosomal agent 33 has favorable human metabolic stability (5.6 mL/min/g liver) and good MDCK membrane permeability (205 nm/sec) but limited aqueous solubility (13 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitrypanosomal agent 33 Related Antibodies
Molecular Weight

288.26

Formula

C13H12N4O4
SMILES

O=C(N/N=C/C1=CC=C([N+]([O-])=O)O1)NCC2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitrypanosomal agent 33 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitrypanosomal agent 33Antitrypanosomal agent33Antitrypanosomal agent-33Parasitehuman lung fibroblastsTrypanosoma cruzi intracellular amastigotestrypanosomiasisMDCK membraneTrypanosoma brucei rhodesienseTrypanosoma brucei bruceiTcNTR Ichagas diseaseTrypanosoma cruzi type I nitroreductaseMRC-5 human lung fibroblastsInhibitorinhibitorinhibit

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HY-184202
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