5-Hydroxyindole-3-acetic acid-d6
Based on 1 Customer Validation
5-Hydroxyindole-3-acetic acid-d6 is the deuterium labeled 5-Hydroxyindole-3-acetic acid. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
For research use only. We do not sell to patients.
- Purity: 99.0%
- Formula: C10H3D6NO3
- Molecular Weight:197.22
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 54-16-0
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Appearance Solid
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Molecular Weight 197.22
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Formula C10H3D6NO3
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SMILES
OC1=C([2H])C(C(C([2H])([2H])C(O)=O)=C([2H])N2)=C2C([2H])=C1[2H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
Ethanol : 50 mg/mL (253.52 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Corcuff JB, et al. Urinary sampling for 5HIAA and metanephrines determination: revisiting the recommendations. Endocr Connect. 2017 Aug;6(6):R87-R98. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 5.0705 mL | 25.3524 mL | 50.7048 mL | 126.7620 mL |
| 5 mM | 1.0141 mL | 5.0705 mL | 10.1410 mL | 25.3524 mL | |
| 10 mM | 0.5070 mL | 2.5352 mL | 5.0705 mL | 12.6762 mL | |
| 15 mM | 0.3380 mL | 1.6902 mL | 3.3803 mL | 8.4508 mL | |
| 20 mM | 0.2535 mL | 1.2676 mL | 2.5352 mL | 6.3381 mL | |
| 25 mM | 0.2028 mL | 1.0141 mL | 2.0282 mL | 5.0705 mL | |
| 30 mM | 0.1690 mL | 0.8451 mL | 1.6902 mL | 4.2254 mL | |
| 40 mM | 0.1268 mL | 0.6338 mL | 1.2676 mL | 3.1690 mL | |
| 50 mM | 0.1014 mL | 0.5070 mL | 1.0141 mL | 2.5352 mL | |
| 60 mM | 0.0845 mL | 0.4225 mL | 0.8451 mL | 2.1127 mL | |
| 80 mM | 0.0634 mL | 0.3169 mL | 0.6338 mL | 1.5845 mL | |
| 100 mM | 0.0507 mL | 0.2535 mL | 0.5070 mL | 1.2676 mL |
5-Hydroxyindole-3-acetic acid-d6 Related Classifications
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