1. Others
    Metabolic Enzyme/Protease
  2. Androgen Receptor
    Drug Metabolite
  3. p,p'-DDE

p,p'-DDE (Synonyms: 4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene)

Cat. No.: HY-B1986
Handling Instructions

p,p'-DDE (4,4'-DDE) inhibits androgen binding to the androgen receptor, androgen-induced transcriptional activity, and androgen action in developing, pubertal and adult male rats.

p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM.

For research use only. We do not sell to patients.

p,p'-DDE Chemical Structure

p,p'-DDE Chemical Structure

CAS No. : 72-55-9

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Description

p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[1].

Molecular Weight

318.03

Formula

C₁₄H₈Cl₄

CAS No.

72-55-9

SMILES

Cl/C(Cl)=C(C1=CC=C(Cl)C=C1)/C2=CC=C(Cl)C=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

p,p'-DDE4,4'-DDEp,p'-DichlorodiphenyldichloroethyleneAndrogen ReceptorDrug MetabolitetranscriptionalmetaboliteantiandrogenicdevelopmentaleffectsinvivoandInhibitorinhibitorinhibit

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