72-55-9
72-55-9
Chemical Structure
p,p'-DDE
Synonym(s): 4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene
- CAS No.: 72-55-9
- Formula:C14H8Cl4
- Molecular Weight:318.03
IUPAC Name: 4,4'-(2,2-dichloroethene-1,1-diyl)bis(chlorobenzene)
InChIKey: UCNVFOCBFJOQAL-UHFFFAOYSA-N
SMILES: Cl/C(Cl)=C(C1=CC=C(Cl)C=C1)/C2=CC=C(Cl)C=C2
Biological Activity: p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
p,p'-DDE | 99.91% | p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
p,p'-DDE (Standard) | ≥98% | p,p'-DDE (Standard) is the analytical standard of p,p'-DDE. This product is intended for research and analytical applications. p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
p,p'-DDE-d8 | 99% | p,p'-DDE-d8 is the deuterium labeled p,p'-DDE. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
p,p'-DDE-13C12 | p,p'-DDE-13C12 is 13C labeled p,p'-DDE. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
o,p'-DDE | 99.95% | o,p'-DDE (2,4-Dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDT. It accumulates in smallmouth buffalo, channel catfish, and largemouth bass, and in sediments from DDT manufacturing plants around the Huntsville Spring Branch-Indian Creek tributary system, where it is considered a persistent organic pollutant (POP). o,p'-DDE inhibits estrogen binding to the rainbow trout estrogen receptor (rtER) with an IC50 value of 3.2 μM. It induces concentration-dependent estradiol secretion in co-cultures of granulosa and theca cells isolated from porcine follicles. In ovo exposure to o,p'-DDE increases follicular degeneration and reduces testis size in Japanese medaka (O. latipes). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Chlorfenethol | Chlorfenethol is a dehydrochlorinase inhibitor. Chlorfenethol can be used as a synergist for insecticide DDT to increase its effect on resistant strains. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
DDOH | DDOH is an effective metabolite of DTT. DDOH can combine with palmitic acid to form conjugates. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
p,p'-DDD | 99.37% | p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
2,4'-Dichlorobenzophenone | 98.52% | 2,4'-Dichlorobenzophenone is a dichlorinated benzophenone and intermediate in the synthesis of selected fungicides and other agricultural products. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
4,4'-Dichlorobenzophenone | 99.93% | 4,4'-Dichlorobenzophenone (Bis (4-chlorophenyl) ketone) is an ERα/ERβ agonist with IC50 values of 40.86 μM and 24.11 μM, respectively. 4,4'-Dichlorobenzophenone induces ER-dependent cancer cell proliferation after long-term exposure. 4,4'-Dichlorobenzophenone can be used for research on breast cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(4-Chlorophenyl)(4-hydroxyphenyl)methanone (Standard) | ≥98% | (4-Chlorophenyl)(4-hydroxyphenyl)methanone (Standard) is the analytical standard of (4-Chlorophenyl)(4-hydroxyphenyl)methanone. This product is intended for research and analytical applications. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
1-Chloro-4-[2-chloro-1-(4-chlorophenyl)ethyl]benzene | 1-Chloro-4-benzene (1,1-Bis (p-chlorophenyl)-2-chloroethane) (Compound DDMS) is the dechlorination reduction product of DDT (insecticide) and DDD. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
p,p'-DDD-13C12 | p,p'-DDD-13C12 is 13C labeled p,p'-DDD. p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
