1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. T-705RMP

T-705RMP 

Cat. No.: HY-136498
Handling Instructions

T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC50 of 601 μM.

For research use only. We do not sell to patients.

T-705RMP Chemical Structure

T-705RMP Chemical Structure

CAS No. : 356783-08-9

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Description

T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC50 of 601 μM[1].

In Vitro

T-705 can be converted to T-705RMP and T-705RTP by cellular kinases; Host cell enzymes can differentiate T-705, T-705RMP, and T-705RTP from the natural nucleotides. The level of inhibition of IMPDH by T-705RMP is about 150-fold weaker than that by Ribavirin monophosphate, and it became apparent that the antiviral effect of T-705 is not a result of the inhibition of the cellular enzyme[1].

Molecular Weight

369.20

Formula

C₁₀H₁₃FN₃O₉P

CAS No.

356783-08-9

SMILES

O[[email protected]]([[email protected]@H]1O)[[email protected]@](N(C=C2F)C(C(C(N)=O)=N2)=O)([H])O[[email protected]@H]1CO[P](O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

T-705RMPDrug MetabolitephosphorylatedmetaboliteIMPDHhostcellsInhibitorinhibitorinhibit

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