Beauverolide Ja
Beauverolide Ja, a cyclotetradepsipeptide, is a potent calmodulin (CaM) inhibitor with a Kd of 0.078 μM and a Ki of 0.39 μM for Ca2+-CaM. Beauverolide Ja is a secondary metabolite of Isaria fumosorosea.
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- CAS No.: 76265-41-3
- Formule: C35H46N4O5
- Masse moléculaire:602.76
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
Fungal Metabolite |
Chemical Information
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CAS No. 76265-41-3
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Masse moléculaire 602.76
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Formule C35H46N4O5
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SMILES
O=C(N[C@H](C(N[C@](C(OC(CC(N1)=O)C(C)CCCC)=O)([H])[C@@H](C)CC)=O)CC2=CC=CC=C2)[C@@H]1CC3=CNC4=CC=CC=C34
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Structure Classification
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Initial Source
Beauveria sp.
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
Pureté et documentation
Références
[1]. Abraham Madariaga-Mazón, et al. Potent anti-calmodulin activity of cyclotetradepsipeptides isolated from Isaria fumosorosea using a newly designed biosensor. Nat Prod Commun. 2015 Jan;10(1):113-6. [Content Brief]
[2]. Qunfang Weng, et al. Secondary Metabolites and the Risks of Isaria fumosorosea and Isaria farinose. Molecules. 2019 Feb 13;24(4):664. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Beauverolide Ja Related Classifications
HY-142087 Related Classifications
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