1-Palmitoyl-sn-glycerol 3-phosphate
Based on 1 Customer Validation
1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA) is a phospholipid and lipid membrane precursor. 1-Palmitoyl-sn-glycerol 3-phosphate integrates into POPC liposomes, causing significant changes in membrane curvature. 1-Palmitoyl-sn-glycerol 3-phosphate induces platelet aggregation, but its activity is 30-fold lower than that of 1-hexadecyl-sn-glyceryl-3-phosphate.
For research use only. We do not sell to patients.
- Purity : 98.3%
- CAS No.: 7220-34-0
- Formula: C19H39O7P
- Molecular Weight:410.48
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
290 nM
Compound: LPA (16:0)
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Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay
Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay
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[PMID: 23395664] |
| HEK293 | EC50 |
580 nM
Compound: LPA (16:0)
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Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay
Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay
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[PMID: 23395664] |
| HEK293 | EC50 |
68 nM
Compound: LPA (16:0)
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Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425
Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425
|
[PMID: 23395664] |
| HEK293 | EC50 |
71 nM
Compound: LPA (16:0)
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Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay
Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay
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[PMID: 23395664] |
| HEK293 | EC50 |
84 nM
Compound: LPA (16:0)
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Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425
Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425
|
[PMID: 23395664] |
| HEK293 | EC50 |
930 nM
Compound: LPA (16:0)
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Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425
Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425
|
[PMID: 23395664] |
In Vitro
1-Palmitoyl-sn-glycerol 3-phosphate induces aggregation of platelet suspensions, with a half-maximal effective concentration (EC50) of 290 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 7220-34-0
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Appearance Solid
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Molecular Weight 410.48
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Formula C19H39O7P
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Color White to off-white
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SMILES
O=P(O)(O)OC[C@H](O)COC(CCCCCCCCCCCCCCC)=O
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Synonyms
1-P-GPA
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 2.5 mg/mL (6.09 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Wick R, et al. Enzyme-containing liposomes can endogenously produce membrane-constituting lipids. Chem Biol. 1996;3(4):277-285. [Content Brief]
[2]. Simon MF, et al. Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: a new group of phospholipid mediators? Biochem Biophys Res Commun. 1982 Oct 29;108(4):1743-50. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4362 mL | 12.1809 mL | 24.3617 mL | 60.9043 mL |
| 5 mM | 0.4872 mL | 2.4362 mL | 4.8723 mL | 12.1809 mL |
1-Palmitoyl-sn-glycerol 3-phosphate Related Classifications
HY-126967A Related Classifications
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Keywords
- 1-Palmitoyl-sn-glycerol 3-phosphate
- 7220-34-0
- 1-P-GPA
- Liposome
- human platelet aggregation
- smaller liposomes
- POPC giant vesicle membranes
- platelet suspensions
- cell-like structure shell multiplication
- human platelets
- POPC/P-CoA giant vesicles
- phosphatidylcholine salvage biosynthesis pathway
- giant vesicle shrinkage
- G3P-AT
- Inhibitor
- inhibitor
- inhibit