1-Palmitoyl-sn-glycerol 3-phosphate (Synonyms: 1-P-GPA)

Cat. No.: HY-126967A Purity: 99.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA) is a phospholipid and lipid membrane precursor. 1-Palmitoyl-sn-glycerol 3-phosphate integrates into POPC liposomes, causing significant changes in membrane curvature. 1-Palmitoyl-sn-glycerol 3-phosphate induces platelet aggregation, but its activity is 30-fold lower than that of 1-hexadecyl-sn-glyceryl-3-phosphate.

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1-Palmitoyl-sn-glycerol 3-phosphate 화학구조

CAS No. : 7220-34-0

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	견적 받기
10 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

Other Forms of 1-Palmitoyl-sn-glycerol 3-phosphate:

1-Palmitoyl-sn-glycerol 3-phosphate sodium salt In-stock
1-Palmitoyl-sn-glycerol 3-phosphate-d₉ 견적 받기

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	290 nM Compound: LPA (16:0)	Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA2 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	EC₅₀	580 nM Compound: LPA (16:0)	Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA3 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	EC₅₀	68 nM Compound: LPA (16:0)	Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
HEK293	EC₅₀	71 nM Compound: LPA (16:0)	Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay Agonist activity at human LPA1 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay	[PMID: 23395664]
HEK293	EC₅₀	84 nM Compound: LPA (16:0)	Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA4 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]
HEK293	EC₅₀	930 nM Compound: LPA (16:0)	Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 Agonist activity at human LPA6 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425	[PMID: 23395664]

In Vitro

1-Palmitoyl-sn-glycerol 3-phosphate induces aggregation of platelet suspensions, with a half-maximal effective concentration (EC₅₀) of 290 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

410.48

화학식

C₁₉H₃₉O₇P

CAS No.

7220-34-0

Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(O)OC[C@H](O)COC(CCCCCCCCCCCCCCC)=O

Structure Classification

Others

Initial Source

Endogenous metabolite

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 2.5 mg/mL (6.09 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4362 mL	12.1809 mL	24.3617 mL
5 mM	0.4872 mL	2.4362 mL	4.8723 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.0%

Select Batch:

Data Sheet (266 KB) SDS (251 KB)

COA (239 KB)

Handling Instructions (2659 KB)

References

[1]. Wick R, et al. Enzyme-containing liposomes can endogenously produce membrane-constituting lipids. Chem Biol. 1996;3(4):277-285. [Content Brief]

[2]. Simon MF, et al. Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: a new group of phospholipid mediators? Biochem Biophys Res Commun. 1982 Oct 29;108(4):1743-50. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4362 mL	12.1809 mL	24.3617 mL	60.9043 mL
DMSO	5 mM	0.4872 mL	2.4362 mL	4.8723 mL	12.1809 mL

1-Palmitoyl-sn-glycerol 3-phosphate Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Palmitoyl-sn-glycerol 3-phosphate7220-34-01-P-GPALiposomehuman platelet aggregationsmaller liposomesPOPC giant vesicle membranesplatelet suspensionscell-like structure shell multiplicationhuman plateletsPOPC/P-CoA giant vesiclesphosphatidylcholine salvage biosynthesis pathwaygiant vesicle shrinkageG3P-ATInhibitorinhibitorinhibit

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1-Palmitoyl-sn-glycerol 3-phosphate (Synonyms: 1-P-GPA)

Other Forms of 1-Palmitoyl-sn-glycerol 3-phosphate:

1-Palmitoyl-sn-glycerol 3-phosphate Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

1-Palmitoyl-sn-glycerol 3-phosphate Related Antibodies

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