(Z)-10-Hydroxynortriptyline-d3
Based on 1 Customer Validation
(Z)-10-Hydroxynortriptyline-d3 is the deuterium labeled (Z)-10-Hydroxynortriptyline (HY-100646A). (Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline (HY-118620). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.0%
- 화학식: C19H18D3NO
- 분자량:282.40
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
신청
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 47132-19-4
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Appearance Solid
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분자량 282.40
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화학식 C19H18D3NO
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Color White to light yellow
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SMILES
OC1C2=CC=CC=C2/C(C3=CC=CC=C3C1)=C\CCNC([2H])([2H])[2H]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMF : ≥ 30 mg/mL (106.23 mM)
DMSO : ≥ 10 mg/mL (35.41 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : ≥ 5 mg/mL (17.71 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
순도&문서
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO / DMF | 1 mM | 3.5411 mL | 17.7054 mL | 35.4108 mL | 88.5269 mL |
| 5 mM | 0.7082 mL | 3.5411 mL | 7.0822 mL | 17.7054 mL | |
| 10 mM | 0.3541 mL | 1.7705 mL | 3.5411 mL | 8.8527 mL | |
| 15 mM | 0.2361 mL | 1.1804 mL | 2.3607 mL | 5.9018 mL | |
| DMSO / DMF | 20 mM | 0.1771 mL | 0.8853 mL | 1.7705 mL | 4.4263 mL |
| 25 mM | 0.1416 mL | 0.7082 mL | 1.4164 mL | 3.5411 mL | |
| 30 mM | 0.1180 mL | 0.5902 mL | 1.1804 mL | 2.9509 mL | |
| DMF | 40 mM | 0.0885 mL | 0.4426 mL | 0.8853 mL | 2.2132 mL |
| 50 mM | 0.0708 mL | 0.3541 mL | 0.7082 mL | 1.7705 mL | |
| 60 mM | 0.0590 mL | 0.2951 mL | 0.5902 mL | 1.4754 mL | |
| 80 mM | 0.0443 mL | 0.2213 mL | 0.4426 mL | 1.1066 mL | |
| 100 mM | 0.0354 mL | 0.1771 mL | 0.3541 mL | 0.8853 mL |
(Z)-10-Hydroxynortriptyline-d3 Related Classifications
HY-100646AS Related Classifications
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