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  3. 7,3',4'-Trihydroxyisoflavone

7,3',4'-Trihydroxyisoflavone 

Cat. No.: HY-124953
Handling Instructions

7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities.

For research use only. We do not sell to patients.

7,3',4'-Trihydroxyisoflavone Chemical Structure

7,3',4'-Trihydroxyisoflavone Chemical Structure

CAS No. : 485-63-2

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Description

7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities[1][2].

In Vitro

7,3',4'-Trihydroxyisoflavone triggers cell cycle arrest at the G1 phase and displays an anti-proliferative effect against EGF receptor-positive skin cancer[1].
7,3',4'-Trihydroxyisoflavone also significantly inhibits UVB-induced COX-2 expression by suppressing the NF-B transcription activity in mouse skin epidermal JB6 P+ cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In a mouse skin tumorigenesis model, 7,3',4'-Trihydroxyisoflavone strongly suppresses the incidence, multiplicity, and volume of UVB-induced mouse skin tumors. Consistent with the tumor data, 7,3',4'-Trihydroxyisoflavone clearly attenuates UVB-induced COX-2 expression in hairless mouse skin[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

270.24

Formula

C15H10O5

CAS No.
SMILES

OC1=CC=C2C(C(C3=CC(O)=C(C=C3)O)=COC2=C1)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
7,3',4'-Trihydroxyisoflavone
Cat. No.:
HY-124953
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