485-63-2
485-63-2
Chemical Structure
7,3',4'-Trihydroxyisoflavone
- CAS No.: 485-63-2
- Formula:C15H10O5
- Molecular Weight:270.24
IUPAC Name: 3-(3,4-dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one
InChIKey: DDKGKOOLFLYZDL-UHFFFAOYSA-N
SMILES: OC1=CC=C2C(C(C3=CC(O)=C(C=C3)O)=COC2=C1)=O
Biological Activity: 7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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7,3',4'-Trihydroxyisoflavone | 99.83% | 7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities. | ||||||||||||||||||||
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7,3',4'-Trihydroxyisoflavone (Standard) | ≥98% | 7,3',4'-Trihydroxyisoflavone (Standard) is the analytical standard of 7,3',4'-Trihydroxyisoflavone. This product is intended for research and analytical applications. 7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities. | ||||||||||||||||||||
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Genistein (Standard) | 98.70% | Genistein (Standard) is the analytical standard of Genistein. This product is intended for research and analytical applications. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis. | ||||||||||||||||||||
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Daidzein (Standard) | 98.65% | Daidzein (Standard) is the analytical standard of Daidzein. This product is intended for research and analytical applications. Daidzein is a soy isoflavone, which acts as a PPAR activator. | ||||||||||||||||||||
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Calycosin | 99.96% | Calycosin is a compound that can be isolated from Radix Astragali. Calycosin has strong antioxidant, anti-inflammatory and apoptosis-modulating effects. Calycosin can be used for the research of ovarian cancer and breast cancer. | ||||||||||||||||||||
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2′-Hydroxydaidzein | 96.04% | 2′-Hydroxydaidzein is a metabolite. 2′-Hydroxydaidzein inhibits the release of chemical mediator from inflammatory cells. 2′-Hydroxydaidzein significantly inhibits lysozyme and β-glucuronidase release from rat neutrophils, which is stimulated with fMLP/CB, respectively. | ||||||||||||||||||||
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3'-Methoxydaidzein | 99.67% | 3'-Methoxydaidzein is a isoflavone and a Sodium Channel inhibitor. 3'-Methoxydaidzein inhibits subtypes NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM, and 505 nM, respectively. 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels. | ||||||||||||||||||||
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Orobol | 98.66% | Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC50=3.46-5.27 μM for PI3K α/β/γ/K/δ). | ||||||||||||||||||||
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Desmethylglycitein (Standard) | ≥98% | Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1). Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes. | ||||||||||||||||||||
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7,3'-Dihydroxy-5'-methoxyisoflavone | 7,3'-Dihydroxy-5'-methoxyisoflavone (Pterosonin E) is an arylcoumarin. 7,3'-Dihydroxy-5'-methoxyisoflavone can be used for various biochemical studies. | |||||||||||||||||||||
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7-Hydroxyisoflavone | 99.75% | 7-Hydroxyisoflavone is an enterovirus replication inhibitor. 7-Hydroxyisoflavone inhibits enterovirus 71 viral RNA synthesis, viral protein synthesis, and early replication steps. 7-Hydroxyisoflavone also inhibits coxsackievirus replication. 7-Hydroxyisoflavone enhances AMPK activity and prevents serum-induced reduction of AMPK phosphorylation. 7-Hydroxyisoflavone can be used in research related to enterovirus infection. | ||||||||||||||||||||
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7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one | 7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one is a dual agonist of PPARα and PPARγ, with an EC50 of 23.10 μM for human PPARα and an EC50 of 22.29 μM for human PPARγ. 7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one regulates the expression of lipid metabolism-related genes via PPARα, and modulates the expression of genes associated with glucose homeostasis and adipogenesis via PPARγ. 7-Hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one can be used in the research of type 2 diabetes and metabolic syndrome. | |||||||||||||||||||||
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References
- [1]. Yu-Li Lo, et al. 7,3',4'-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species. Toxicology. 2012 Dec 16;302(2-3):221-32. [Content Brief]
- [2]. Dong Eun Lee, et al. 7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4. J Biol Chem. 2011 Apr 22;286(16):14246-56. [Content Brief]
