485-63-2
485-63-2
Chemical Structure
7,3',4'-Trihydroxyisoflavone
- CAS No.: 485-63-2
- Formula:C15H10O5
- Molecular Weight:270.24
IUPAC Name: 3-(3,4-dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one
InChIKey: DDKGKOOLFLYZDL-UHFFFAOYSA-N
SMILES: OC1=CC=C2C(C(C3=CC(O)=C(C=C3)O)=COC2=C1)=O
Biological Activity: 7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities[1][2].
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7,3',4'-Trihydroxyisoflavone | 99.83% | 7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities. | ||||||||||||||||||||
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7,3',4'-Trihydroxyisoflavone (Standard) | ≥98% | 7,3',4'-Trihydroxyisoflavone (Standard) is the analytical standard of 7,3',4'-Trihydroxyisoflavone. This product is intended for research and analytical applications. 7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities. | ||||||||||||||||||||
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References
- [1]. Yu-Li Lo, et al. 7,3',4'-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species. Toxicology. 2012 Dec 16;302(2-3):221-32. [Content Brief]
- [2]. Dong Eun Lee, et al. 7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4. J Biol Chem. 2011 Apr 22;286(16):14246-56. [Content Brief]
