1. GPCR/G Protein
  2. Prostaglandin Receptor

MRE-269 (Synonyms: ACT-333679)

Cat. No.: HY-79593 Purity: 99.91%
Handling Instructions

MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.

For research use only. We do not sell to patients.
MRE-269 Chemical Structure

MRE-269 Chemical Structure

CAS No. : 475085-57-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 177 In-stock
2 mg USD 84 In-stock
5 mg USD 192 In-stock
10 mg USD 336 In-stock
50 mg USD 1320 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.

In Vitro

MRE-269 induces endothelium-independent vasodilation of rat extralobar pulmonary artery (EPA). MRE-269 or other IP receptor agonists including epoprostenol, iloprost, treprostinil and beraprost increase cAMP levels in hPASMC[1]. MRE-269 induces concentration-dependent vasodilation in LPA(+), LPA(-), and SPA(-)[3].

In Vivo

The vasorelaxant effects of MRE-269 on rat small intralobar pulmonary artery (SIPA) and EPA are the same, while the other IP receptor agonists induce less vasodilation in SIPA than in EPA[1]. MRE-269 produces substantial relaxation of rat small pulmonary artery, although its effects are only significant at high concentrations of above 10 μM (pEC50, 4.98±0.22). By contrast, in rat small pulmonary veins, MRE-269 only produces minimal relaxation over the whole concentration range, with only significant relaxation occurring at the two highest doses of MRE-269 of 10 and 100 μM[2].

References
Molecular Weight

419.52

Formula

C₂₅H₂₉N₃O₃

CAS No.

475085-57-5

SMILES

OC(COCCCCN(C(C)C)C1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)N=C1)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 51 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MRE-269
Cat. No.:
HY-79593
Quantity: