1. Metabolic Enzyme/Protease
  2. Cytochrome P450

Salvianolic acid C 

Cat. No.: HY-N0319
Handling Instructions

Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with Kis of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.

For research use only. We do not sell to patients.

Salvianolic acid C Chemical Structure

Salvianolic acid C Chemical Structure

CAS No. : 115841-09-3

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with Kis of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.

IC50 & Target

CYP2C8

4.82 μM (Ki)

CYP2J2

5.75 μM (Ki)

In Vitro

Salvianolic acid C is a noncompetitive CYP2C8 inhibitor and a moderate mixed inhibitor of CYP2J2, with Kis of 4.82, 5.75 μM for CYP2C8 and CYP2J2, respectively[1]. 1 and 5 μM Salvianolic acid C (SalC) could significantly inhibit the NO production induced by LPS. Salvianolic acid C decreases the expression of iNOS significantly. Salvianolic acid C inhibits LPS-induced TNF-α, IL-1β, IL-6 and IL-10 overproduction. Salvianolic acid C inhibits LPS-induced NF‑κB activation. Salvianolic acid C also increases the expression of Nrf2 and HO-1 in BV2 microglial cells[2].

In Vivo

Salvianolic acid C (20 mg/kg) treatment could significantly decrease the escape latency. In addition, SalC (10 and 20 mg/kg) treatment significantly increase the platform crossing number compared with the LPS model group. Systemic administration of Salvianolic acid C down regulates the brain TNF-α, IL-1β and IL-6 levels compared with the model group. The iNOS and COX-2 levels in rat brain cortex and hippocampus are higher than that in the control group, while Salvianolic acid C treatment significantly down regulates the cortex and hippocampus regions. Salvianolic acid C (5, 10 and 20 mg/kg) treatment dose-dependently increases the p-AMPK, Nrf2, HO-1 and NQO1 levels in rat brain cortex and hippocampus[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0307 mL 10.1537 mL 20.3075 mL
5 mM 0.4061 mL 2.0307 mL 4.0615 mL
10 mM 0.2031 mL 1.0154 mL 2.0307 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

492.43

Formula

C₂₆H₂₀O₁₀

CAS No.

115841-09-3

SMILES

OC1=C(O)C=CC(C[[email protected]](C(O)=O)OC(/C=C/C2=CC=C(O)C3=C2C=C(C4=CC(O)=C(O)C=C4)O3)=O)=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Salvianolic acid C
Cat. No.:
HY-N0319
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Salvianolic acid C

Cat. No.: HY-N0319