Salvianolic acid C

Name: Salvianolic acid C
Brand: MedChemExpress
SKU: HY-N0319
Rating: 5.0 (6 reviews)

Cat. No.: HY-N0319 Purity: 99.31%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with K_is of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.

For research use only. We do not sell to patients.

CAS No. : 115841-09-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Salvianolic acid C:

Salvianolic acid C (Standard) Get quote

6 Publications Citing Use of MCE Salvianolic acid C

Flow Cytometry

ELISA

Cell Imaging/Staining

In Vivo Efficacy Study

: Salvianolic acid C purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Dec 2;134(23):e181612. [Abstract]; BMDCs from WT mice were treated with 20 μM Salvianolic acid C (SAC) for 24 hours, and the expression of cathepsins A and B was detected by Western blotting.

: Salvianolic acid C purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Dec 2;134(23):e181612. [Abstract]; BMDCs from WT mice were pretreated with Salvianolic acid C (SAC) (20 μM) for 24 hours and then cocultured with 40 Gy–pretreated or nonirradiated B16-OZ cells for 8 hours. Purified CD11c⁺ cells were incubated for another 2 days, and the supernatants were collected to measure IFN-β.

: Salvianolic acid C purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Dec 2;134(23):e181612. [Abstract]; B16-OVA tumor–bearing mice were treated with IR (20 Gy, 1 dose) and antigen-pulsed BMDCs from WT mice with or without Salvianolic acid C (SAC) treatment (twice weekly by i.t. injection).

: Salvianolic acid C purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2022 Nov 22;15(12):1444.; Dox increased human platelet phagocytosis by differentiated THP-1 macrophages. Platelets were stained with CMFDA and then co-incubated with differentiated THP-1 cells and 40 μg/mL Dox pretreated with or without Salvianolic acid C (SAC) (40 µM). THP-1 cells were washed to remove platelets and analyzed for CMFDA signal by flow cytometry.

: Salvianolic acid C purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2022 Nov 22;15(12):1444.; Salvianolic acid C (SAC) (20 μM) could ameliorate Dox induced cancer cell-platelet Interaction.

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View All Cytochrome P450 Isoform Specific Products:

View All Isoforms

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

CYP2C8

4.82 μM (Ki)

CYP2J2

5.75 μM (Ki)

In Vitro

Salvianolic acid C is a noncompetitive CYP2C8 inhibitor and a moderate mixed inhibitor of CYP2J2, with K_is of 4.82, 5.75 μM for CYP2C8 and CYP2J2, respectively^[1]. 1 and 5 μM Salvianolic acid C (SalC) could significantly inhibit the NO production induced by LPS. Salvianolic acid C decreases the expression of iNOS significantly. Salvianolic acid C inhibits LPS-induced TNF-α, IL-1β, IL-6 and IL-10 overproduction. Salvianolic acid C inhibits LPS-induced NF κB activation. Salvianolic acid C also increases the expression of Nrf2 and HO-1 in BV2 microglial cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Salvianolic acid C (20 mg/kg) treatment could significantly decrease the escape latency. In addition, SalC (10 and 20 mg/kg) treatment significantly increase the platform crossing number compared with the LPS model group. Systemic administration of Salvianolic acid C down regulates the brain TNF-α, IL-1β and IL-6 levels compared with the model group. The iNOS and COX-2 levels in rat brain cortex and hippocampus are higher than that in the control group, while Salvianolic acid C treatment significantly down regulates the cortex and hippocampus regions. Salvianolic acid C (5, 10 and 20 mg/kg) treatment dose-dependently increases the p-AMPK, Nrf2, HO-1 and NQO1 levels in rat brain cortex and hippocampus^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

492.43

Formula

C₂₆H₂₀O₁₀

CAS No.

115841-09-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=C(O)C=CC(C[C@H](C(O)=O)OC(/C=C/C2=CC=C(O)C3=C2C=C(C4=CC(O)=C(O)C=C4)O3)=O)=C1

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (101.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0307 mL	10.1537 mL	20.3075 mL
5 mM	0.4061 mL	2.0307 mL	4.0615 mL
10 mM	0.2031 mL	1.0154 mL	2.0307 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.08 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.08 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.94%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (249 KB) HNMR (172 KB) RP-HPLC (75 KB)

Handling Instructions (2659 KB)

References

[1]. Xu MJ, et al. Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2. Chem Biol Interact. 2018 Jun 1;289:15-22. [Content Brief]

[2]. Song J, et al. Activation of Nrf2 signaling by salvianolic acid C attenuates NF‑κB mediated inflammatory response both in vivo and in vitro. Int Immunopharmacol. 2018 Oct;63:299-310. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0307 mL	10.1537 mL	20.3075 mL	50.7686 mL
	5 mM	0.4061 mL	2.0307 mL	4.0615 mL	10.1537 mL
	10 mM	0.2031 mL	1.0154 mL	2.0307 mL	5.0769 mL
	15 mM	0.1354 mL	0.6769 mL	1.3538 mL	3.3846 mL
	20 mM	0.1015 mL	0.5077 mL	1.0154 mL	2.5384 mL
	25 mM	0.0812 mL	0.4061 mL	0.8123 mL	2.0307 mL
	30 mM	0.0677 mL	0.3385 mL	0.6769 mL	1.6923 mL
	40 mM	0.0508 mL	0.2538 mL	0.5077 mL	1.2692 mL
	50 mM	0.0406 mL	0.2031 mL	0.4061 mL	1.0154 mL
	60 mM	0.0338 mL	0.1692 mL	0.3385 mL	0.8461 mL
	80 mM	0.0254 mL	0.1269 mL	0.2538 mL	0.6346 mL
	100 mM	0.0203 mL	0.1015 mL	0.2031 mL	0.5077 mL