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Cysteine thiol probe 

Cat. No.: HY-135235
Handling Instructions

Cysteine Thiol Probe is a thiol-based probe designed to label electrophilic natural products. Cysteine Thiol Probe possesses each of the characteristics of an ideal pharmacophore probe, and has a chromophore. Cysteine Thiol Probe is capable of engaging enone-, β-lactam-, and β-lactone-based electrophilic metabolites.

For research use only. We do not sell to patients.

Cysteine thiol probe Chemical Structure

Cysteine thiol probe Chemical Structure

CAS No. : 1947408-74-3

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Description

Cysteine Thiol Probe is a thiol-based probe designed to label electrophilic natural products. Cysteine Thiol Probe possesses each of the characteristics of an ideal pharmacophore probe, and has a chromophore. Cysteine Thiol Probe is capable of engaging enone-, β-lactam-, and β-lactone-based electrophilic metabolites[1][2].

In Vitro

Cysteine Thiol Probe (Probe 1) reacts much more readily with β-lactam- and β-lactone-based electrophilic natural products, and its reactivity with epoxide-based electrophilic natural products is poor. And probe 2 reacts much faster with epoxide-containing natural products. This orthogonal reactivity allows them to be employed in extracts simultaneously. Since Cysteine Thiol Probe is brominated and probe 2 is chlorinated, the isotopic patterns of labeled natural products point toward their structural origin. Competition experiments using Cysteine Thiol Probe and 2 indicated that brominated Cysteine Thiol Probe reacted exclusively with the β-lactam in penicillin G and the β-lactone in salinosporamide A while chlorinated probe 2 alone reacted with the epoxide in salinamide A[1].

Molecular Weight

318.19

Formula

C₁₁H₁₂BrNO₃S

CAS No.

1947408-74-3

SMILES

SC[[email protected]@H](C(OC)=O)NC(C1=CC=C(Br)C=C1)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Cysteine thiol probeOthersNaturalproductsl-cystinepharmacophorechromophoreelectrophilicenone-basedβ-lactam-basedβ-lactone-basedthiol-basedInhibitorinhibitorinhibit

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Cysteine thiol probe
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HY-135235
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