Crustecdysone  (Synonyms: 20-Hydroxyecdysone)

Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP^[1]. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system^[2]. Crustecdysone is an active metabolite of Ecdysone (HY-N0179)^[3].

Crustecdysone induces cell autophagy and caspase-3 activity in the remodeling fat body of Drosophila^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Crustecdysone (5 or 10 mg/kg; i.p., once daily, for 6 weeks) reduces blood pressure and prevents dilated cardiac hypertrophy in SHR rats^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

480.63

Solid

C₂₇H₄₄O₇

5289-74-7

O[C@@H]1[C@H](O)C[C@](C(C=C2[C@]3([H])CC[C@@]4(C)[C@@]2(O)CC[C@]4([H])[C@](O)(C)[C@H](O)CCC(O)(C)C)=O)([H])[C@]3(C)C1

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Liu H, et al. E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy and caspase activity in Drosophila fat body. Insect Biochem Mol Biol. 2014 Feb;45:30-9.  [Content Brief]

  [2]. Phungphong S, et al. 20-Hydroxyecdysone attenuates cardiac remodeling in spontaneously hypertensive rats. Steroids. 2017 Oct;126:79-84.  [Content Brief]

  [3]. Minglei Lu, et al. Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities. Cell Physiol Biochem. 2018;49(4):1633-1645.  [Content Brief]