1. Apoptosis
    Autophagy
    Metabolic Enzyme/Protease
  2. Caspase
    Autophagy
    Endogenous Metabolite
  3. Crustecdysone

Crustecdysone (Synonyms: 20-Hydroxyecdysone)

Cat. No.: HY-N6979 Purity: 99.64%
Handling Instructions

Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Cyanotis arachnoides C.B.Clarke which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system. Crustecdysone is an active metabolite of Ecdysone (α-Ecdysone; HY-N0179)

For research use only. We do not sell to patients.

Crustecdysone Chemical Structure

Crustecdysone Chemical Structure

CAS No. : 5289-74-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 215 In-stock
Estimated Time of Arrival: December 31
100 mg USD 365 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Cyanotis arachnoides C.B.Clarke which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1]. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. Crustecdysone is an active metabolite of Ecdysone (α-Ecdysone; HY-N0179)[3]

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

480.63

Formula

C₂₇H₄₄O₇

CAS No.

5289-74-7

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (260.08 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0806 mL 10.4030 mL 20.8060 mL
5 mM 0.4161 mL 2.0806 mL 4.1612 mL
10 mM 0.2081 mL 1.0403 mL 2.0806 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Crustecdysone20-HydroxyecdysoneCaspaseAutophagyEndogenous MetaboliteecdysteroidhormoneecdysismetamorphosisarthropodsactivemetaboliteEcdysoneα-EcdysoneInhibitorinhibitorinhibit

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Crustecdysone
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