1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. Resolvin D2

Resolvin D2 (Synonyms: RvD2)

Cat. No.: HY-121636
Handling Instructions

Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons.

For research use only. We do not sell to patients.

Resolvin D2 Chemical Structure

Resolvin D2 Chemical Structure

CAS No. : 810668-37-2

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Description

Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].

IC50 & Target

TRP Channel[3]

In Vivo

Resolvin D2 induces active resolution of inflammation with pulp-like tissue regeneration after root canal infection and thus maybe suitable for treating periapical lesions[1].
Resolvin D2 decreases leukocyte:endothelial interactions in vivo by endothelial-dependent nitric oxide production, and direct modulation of leukocyte adhesion receptor expression[2].
Peripheral administration of Resolvin D2 (10 ng; Intraplantar administration) potently inhibits inflammatory pain[3].

Animal Model: Adult CD1 mice (male, 8–10 weeks)[3]
Dosage: 10 ng
Administration: Intraplantar administration
Result: Inhibited inflammatory pain.
Molecular Weight

376.49

Formula

C₂₂H₃₂O₅

CAS No.

810668-37-2

SMILES

CC/C=C\C[[email protected]](O)[[email protected]](O)/C=C/C=C/C=C\C=C\[[email protected]@H](O)C/C=C\CCC(O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Resolvin D2RvD2Resolvin D 2Resolvin D-2RvD 2RvD-2TRP ChannelTransient receptor potential channelsTRPV1TRPA1Inhibitorinhibitorinhibit

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Resolvin D2
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