1. Anti-infection
  2. Influenza Virus
    Parasite
  3. Cletoquine

Cletoquine (Synonyms: Desethylhydroxychloroquine)

Cat. No.: HY-135810
Handling Instructions

Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment.

For research use only. We do not sell to patients.

Cletoquine Chemical Structure

Cletoquine Chemical Structure

CAS No. : 4298-15-1

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Description

Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

IC50 & Target

Chikungunya virus (CHIKV)[2]

In Vivo

Hydroxychloroquine (5 mg/kg intravenously) is administered to BALB/c mice for blood and tissue to determine the content of Cletoquine (Desethylhydroxychloroquine). The tissue to blood concentration ratio (Kp) is ≥1, indicating accumulation of Cletoquine in tissues. The Cletoquine Kp ratio for the various tissues are observed in the descending order of liver (114.3)>kidney (24.4)>spleen (19.3)>lungs (16.5)>heart (5.5)[3].

Molecular Weight

307.82

Formula

C₁₆H₂₂ClN₃O

CAS No.

4298-15-1

SMILES

CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CletoquineDesethylhydroxychloroquineInfluenza VirusParasiteHydroxychloroquineNdesethylationCYP2D6CYP3A4CYP3A5CYP2C8antimalarialP23pro-zbdCHIKVantiviralInhibitorinhibitorinhibit

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Cletoquine
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HY-135810
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