1. Anti-infection
  2. Influenza Virus
    Parasite
  3. Cletoquine oxalate

Cletoquine oxalate (Synonyms: Desethylhydroxychloroquine oxalate)

Cat. No.: HY-135810A
Handling Instructions

Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment.

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Cletoquine oxalate Chemical Structure

Cletoquine oxalate Chemical Structure

CAS No. : 14142-64-4

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Description

Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

IC50 & Target

Chikungunya virus (CHIKV)[2]

In Vivo

Hydroxychloroquine (5 mg/kg intravenously) is administered to BALB/c mice for blood and tissue to determine the content of Cletoquine (Desethylhydroxychloroquine). The tissue to blood concentration ratio (Kp) is ≥1, indicating accumulation of Cletoquine in tissues. The Cletoquine Kp ratio for the various tissues are observed in the descending order of liver (114.3)>kidney (24.4)>spleen (19.3)>lungs (16.5)>heart (5.5)[3].

Molecular Weight

397.85

Formula

C₁₈H₂₄ClN₃O₅

CAS No.

14142-64-4

SMILES

CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCCO.O=C(O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CletoquineDesethylhydroxychloroquineInfluenza VirusParasiteHydroxychloroquineNdesethylationCYP2D6CYP3A4CYP3A5CYP2C8antimalarialP23pro-zbdCHIKVantiviralInhibitorinhibitorinhibit

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Cletoquine oxalate
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HY-135810A
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