2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Edoxaban M4

Edoxaban M4  (Synonyms: D21-2393)

Cat. No.: HY-119124 Purity: 99.13%
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Edoxaban M4, an active metabolite of Edoxaban, shows reproducible, but concentration-dependent matrix effects. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor .

For research use only. We do not sell to patients.

Edoxaban M4 Chemical Structure

Edoxaban M4 Chemical Structure

CAS No. : 834919-19-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 440 In-stock
Solution
10 mM * 1 mL in DMSO USD 440 In-stock
Solid
5 mg USD 400 In-stock
10 mg USD 680 In-stock
25 mg USD 1250 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Edoxaban M4 Related Antibodies

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Description

Edoxaban M4, an active metabolite of Edoxaban, shows reproducible, but concentration-dependent matrix effects. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor [1][2].

Molecular Weight

520.99

Formula

C22H25ClN6O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H]1C[C@H]([C@H](CC1)NC(C(NC2=NC=C(C=C2)Cl)=O)=O)NC(C3=NC4=C(CN(CC4)C)S3)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (47.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9194 mL 9.5971 mL 19.1942 mL
5 mM 0.3839 mL 1.9194 mL 3.8388 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9194 mL 9.5971 mL 19.1942 mL 47.9856 mL
5 mM 0.3839 mL 1.9194 mL 3.8388 mL 9.5971 mL
10 mM 0.1919 mL 0.9597 mL 1.9194 mL 4.7986 mL
15 mM 0.1280 mL 0.6398 mL 1.2796 mL 3.1990 mL
20 mM 0.0960 mL 0.4799 mL 0.9597 mL 2.3993 mL
25 mM 0.0768 mL 0.3839 mL 0.7678 mL 1.9194 mL
30 mM 0.0640 mL 0.3199 mL 0.6398 mL 1.5995 mL
40 mM 0.0480 mL 0.2399 mL 0.4799 mL 1.1996 mL
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Edoxaban M4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Edoxaban M4834919-19-6D21-2393Edoxaban M 4Edoxaban M-4Drug MetaboliteFXamatrixeffectfactorXaEdoxabanInhibitorinhibitorinhibit

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