Larsucosterol sodium  (Synonyms: DUR-928 sodium)

Larsucosterol (DUR-928) sodium, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol sodium as a potent endogenous regulator decreases lipogenesis. Larsucosterol sodium inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1^[1][2][3].

Larsucosterol (DUR-928; 0-25 μM; 8 h; HepG2 cells) sodium inhibits cholesterol biosynthesis by decreasing HMG-CoA reductase mRNA levels and decreases free [¹⁴C] cholesterol in a dose-dependent manner^[1].
Larsucosterol (0-25 μM; 6 h; HepG2 cells) sodium inhibits HMG-CoA reductase expression by inhibition of both SREBP1 activation and expression in hepatocytes^[1].
Larsucosterol (0-50 μM; 48 h) sodium increases cell proliferation and decreases apoptosis in macrophages^[2].
Larsucosterol (0-25 μM; 48 h; macrophages) sodium inhibits activation of liver oxysterol receptor LXRα^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Larsucosterol (DUR-928; 25 mg/kg; i.p.; twice in 14 hours; C57BL/6J mice with nonalcoholic fatty liver diseases (NAFLD) model) sodium reduces serum lipid levels in mice fed a high-fat diet^[3].
Larsucosterol (25 mg/kg; i.p.; twice in 14 hours; C57BL/6J mice with nonalcoholic fatty liver diseases (NAFLD) model) sodium suppressed the expression of the genes and inhibits ABCA1 expressionde. Larsucosterolcreases nuclear SREBP-1 Protein levels and cytoplasmic FAS and ACC1 protein levels in liver tissue^[3].
Larsucosterol (25 mg/kg; i.p.; once every 3 days for 6 weeks; C57BL/6J mice with nonalcoholic fatty liver diseases (NAFLD) model) sodium protects the liver from injury by suppressing hepatic inflammation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

504.70

C₂₇H₄₅NaO₅S

1174047-40-5

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)OS(=O)(O[Na])=O)=CC3)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ren S, et, al. Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes. Biochem Biophys Res Commun. 2007 Sep 7;360(4):802-8.  [Content Brief]

  [2]. Ma Y, et, al. 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway. Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1369-79.  [Content Brief]

  [3]. Xu L, et, al. 5-cholesten-3β,25-diol 3-sulfate decreases lipid accumulation in diet-induced nonalcoholic fatty liver disease mouse model. Mol Pharmacol. 2013 Mar;83(3):648-58.  [Content Brief]