4'-Hydroxytamoxifen
Based on 1 Customer Validation
4'-Hydroxytamoxifen is a metabolite of Tamoxifen. 4'-Hydroxytamoxifen shows higher affinity for the ER than Tamoxifen. 4'-Hydroxytamoxifen induces a non-apoptotic cytotoxic effect in human endometrial adenocarcinoma cells.
For research use only. We do not sell to patients.
- Purity: 99.2%
- CAS No.: 82413-23-8
- Formula: C26H29NO2
- Molecular Weight:387.51
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
0.0033 μM
Compound: 4-OHT
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Antiproliferative activity against human MCF7 cells after 5 days by coulter counter analysis
Antiproliferative activity against human MCF7 cells after 5 days by coulter counter analysis
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[PMID: 27529700] |
| MCF7 | IC50 |
22 μM
Compound: 4-OHT
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Antiproliferative activity against human tamoxifen-resistant MCF7 cells after 5 days by coulter counter analysis
Antiproliferative activity against human tamoxifen-resistant MCF7 cells after 5 days by coulter counter analysis
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[PMID: 27529700] |
| MCF7 | IC50 |
9.5 μM
Compound: 4-OHT
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 32283297] |
| T47D | IC50 |
0.024 μM
Compound: 4-OHT
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Antiproliferative activity against human T47D cells after 5 days by coulter counter analysis
Antiproliferative activity against human T47D cells after 5 days by coulter counter analysis
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[PMID: 27529700] |
| T47D | IC50 |
0.54 μM
Compound: 4-OHT
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Antiproliferative activity against human tamoxifen-resistant T47D cells over-expressing PKC-alpha after 5 days by coulter counter analysis
Antiproliferative activity against human tamoxifen-resistant T47D cells over-expressing PKC-alpha after 5 days by coulter counter analysis
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[PMID: 27529700] |
Chemical Information
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CAS No. 82413-23-8
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Appearance Solid
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Molecular Weight 387.51
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Formula C26H29NO2
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Color White to off-white
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SMILES
CC/C(C1=CC=C(C=C1)O)=C(C2=CC=C(C=C2)OCCN(C)C)\C3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMF : 20 mg/mL (51.61 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF | 1 mM | 2.5806 mL | 12.9029 mL | 25.8058 mL | 64.5145 mL |
| 5 mM | 0.5161 mL | 2.5806 mL | 5.1612 mL | 12.9029 mL | |
| 10 mM | 0.2581 mL | 1.2903 mL | 2.5806 mL | 6.4514 mL | |
| 15 mM | 0.1720 mL | 0.8602 mL | 1.7204 mL | 4.3010 mL | |
| 20 mM | 0.1290 mL | 0.6451 mL | 1.2903 mL | 3.2257 mL | |
| 25 mM | 0.1032 mL | 0.5161 mL | 1.0322 mL | 2.5806 mL | |
| 30 mM | 0.0860 mL | 0.4301 mL | 0.8602 mL | 2.1505 mL | |
| 40 mM | 0.0645 mL | 0.3226 mL | 0.6451 mL | 1.6129 mL | |
| 50 mM | 0.0516 mL | 0.2581 mL | 0.5161 mL | 1.2903 mL |
4'-Hydroxytamoxifen Related Classifications
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