Art. -Nr.: HY-W010476

2,3,5-Trimethylpyrazine

Name: 2,3,5-Trimethylpyrazine
Brand: MedChemExpress
SKU: HY-W010476
Price: 25.00 USD
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2,3,5-Trimethylpyrazine is an activator of OR5K1 with an EC₅₀ of 65.03 μM in Hana-3A cells. 2,3,5-Trimethylpyrazine inhibits ZEN biosynthetic gene expression, disrupts cell membrane phospholipid composition, and inhibits mycelial growth. 2,3,5-Trimethylpyrazine inhibits DNA synthesis in the chorioallantoic membrane without disrupting vascular pattern formation. 2,3,5-Trimethylpyrazine inhibits ciliary beating frequency, oocyte pickup, and infundibular smooth muscle contraction in hamster oviduct explants. 2,3,5-Trimethylpyrazine is useful for research related to plant fungal infections.

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Reinheit : 99.92%
CAS. Nr.: 14667-55-1
Formel: C₇H₁₀N₂
Molecular Weight:122.17

Speicherung:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

2,3,5-Trimethylpyrazine Chemical Structure

CAS. Nr.: 14667-55-1

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

2,3,5-Trimethylpyrazine (0.1-1000 μM; 2 h) is a potent agonist of OR5K1 expressed in Hana-3A cells, with an EC₅₀ of 65.03 μM^[2].
2,3,5-Trimethylpyrazine (0.1-1000 μM; 2 h) synergistically enhances TMP-induced activation of OR5K1 in Hana-3A cells at FA concentrations of 500 μmol/L and 1000 μmol/L^[2].
2,3,5-Trimethylpyrazine (0.1-1000 μM; 2 h) synergistically enhances FA-induced activation of OR2W1 in Hana-3A cells, resulting in an approximately 40% increase in signal^[2].
2,3,5-Trimethylpyrazine (0.1 pM-10 μM) inhibits ciliary beat frequency in hamster oviductal explants^[6].
2,3,5-Trimethylpyrazine (0.1 pM-10 μM) inhibits oocyte pickup rate in hamster oviductal explants^[6].
2,3,5-Trimethylpyrazine (0.1 pM-10 μM) inhibits infundibular smooth muscle contraction in hamster oviductal explants^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Animal Model:

ICA (male, 25-35 g)^[3]
Dosage:

4; 6; 8 mg/kg
Administration:

i.p.; single dose; 1 hr prior to MES induction
Result:

Afforded 15% protection at 4 mg/kg, 45% protection at 6 mg/kg, and 93% protection at 8 mg/kg against MES-induced seizures.
Achieved an ED50 of 6.01 mg/kg with 50% protection from seizures.
Demonstrated anticonvulsant activity comparable to diphenylhydantoin (ED₅₀ 4.83 mg/kg).

Chemical Information

CAS. Nr. 14667-55-1
Appearance Liquid (Density: 0.979 g/cm³)
Molecular Weight 122.17
Formel C₇H₁₀N₂
Color Colorless to light yellow
SMILES

CC1=CN=C(C)C(C)=N1
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (818.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

8.1853 mL

40.9266 mL

81.8532 mL

5 mM

1.6371 mL

8.1853 mL

16.3706 mL

10 mM

0.8185 mL

4.0927 mL

8.1853 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (40.93 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (20.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 3

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (20.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (286 KB)
SDS (605 KB)
- English - EN (605 KB)
- Français - FR (605 KB)
- Deutsch - DE (605 KB)
- Norwegian - NO (605 KB)
- Español - ES (605 KB)
- Swedish - SV (605 KB)
- Italian - IT (605 KB)
- Korean - KR (605 KB)
- Portuguese - PT (605 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gao Y. Comprehensive chemical characterization of Alcoholic beverages and discovery of bioactive components regulating alcohol metabolism enzyme activities. npj Science of Food. 2026 Aug 4.

[2]. Hu B, et al. Elucidating odorant synergy in red wine: through olfactory receptor-based profiling. NPJ science of food. 2026 Mar 14;10(1):141.

[3]. Huang H. Bacterial pyrazine volatiles: A novel approach to inhibit Fusarium graminearum growth and mycotoxin production. Food Bioscience. 2025 Mar 1;65:106059.

[4]. Osada K, et al. Structure-Activity Relationships of Alkylpyrazine Analogs and Fear-Associated Behaviors in Mice. Journal of chemical ecology. 2017 Mar;43(3):263-272.

[5]. Melkonian G, et al. Growth and angiogenesis are inhibited in vivo in developing tissues by pyrazine and its derivatives. Toxicological sciences : an official journal of the Society of Toxicology. 2003 Oct;75(2):393-401.

[6]. Riveles K, et al. Pyrazine derivatives in cigarette smoke inhibit hamster oviductal functioning. Reproductive biology and endocrinology : RB&E. 2004 May 12;2:23.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	8.1853 mL	40.9266 mL	81.8532 mL	204.6329 mL
	5 mM	1.6371 mL	8.1853 mL	16.3706 mL	40.9266 mL
	10 mM	0.8185 mL	4.0927 mL	8.1853 mL	20.4633 mL
	15 mM	0.5457 mL	2.7284 mL	5.4569 mL	13.6422 mL
	20 mM	0.4093 mL	2.0463 mL	4.0927 mL	10.2316 mL
	25 mM	0.3274 mL	1.6371 mL	3.2741 mL	8.1853 mL
	30 mM	0.2728 mL	1.3642 mL	2.7284 mL	6.8211 mL
	40 mM	0.2046 mL	1.0232 mL	2.0463 mL	5.1158 mL
	50 mM	0.1637 mL	0.8185 mL	1.6371 mL	4.0927 mL
	60 mM	0.1364 mL	0.6821 mL	1.3642 mL	3.4105 mL
	80 mM	0.1023 mL	0.5116 mL	1.0232 mL	2.5579 mL
	100 mM	0.0819 mL	0.4093 mL	0.8185 mL	2.0463 mL

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2,3,5-Trimethylpyrazine

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen