2,3,5-Trimethylpyrazine

Name: 2,3,5-Trimethylpyrazine
Brand: MedChemExpress
SKU: HY-W010476
Rating: 4.5 (1 reviews)

Cat. No.: HY-W010476 Purity: 99.86%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

2,3,5-Trimethylpyrazine is an endogenous metabolite.

For research use only. We do not sell to patients.

2,3,5-Trimethylpyrazine Chemical Structure

CAS No. : 14667-55-1

Size	Price	Stock	Quantity
500 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
5 g	USD 35	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 2,3,5-Trimethylpyrazine:

2,3,5-Trimethylpyrazine-d₉ Get quote

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Biological Activity
Purity & Documentation
Customer Review

Description

2,3,5-Trimethylpyrazine is an endogenous metabolite.

IC₅₀ & Target

Human Endogenous Metabolite

Molecular Weight

122.17

Formula

C₇H₁₀N₂

CAS No.

14667-55-1

Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC1=CN=C(C)C(C)=N1

Structure Classification

Others

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (818.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.1853 mL	40.9266 mL	81.8532 mL
5 mM	1.6371 mL	8.1853 mL	16.3706 mL
10 mM	0.8185 mL	4.0927 mL	8.1853 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (20.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (20.46 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (247 KB) SDS (544 KB)

COA (249 KB) HNMR (119 KB) GC (75 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	8.1853 mL	40.9266 mL	81.8532 mL	204.6329 mL
	5 mM	1.6371 mL	8.1853 mL	16.3706 mL	40.9266 mL
	10 mM	0.8185 mL	4.0927 mL	8.1853 mL	20.4633 mL
	15 mM	0.5457 mL	2.7284 mL	5.4569 mL	13.6422 mL
	20 mM	0.4093 mL	2.0463 mL	4.0927 mL	10.2316 mL
	25 mM	0.3274 mL	1.6371 mL	3.2741 mL	8.1853 mL
	30 mM	0.2728 mL	1.3642 mL	2.7284 mL	6.8211 mL
	40 mM	0.2046 mL	1.0232 mL	2.0463 mL	5.1158 mL
	50 mM	0.1637 mL	0.8185 mL	1.6371 mL	4.0927 mL
	60 mM	0.1364 mL	0.6821 mL	1.3642 mL	3.4105 mL
	80 mM	0.1023 mL	0.5116 mL	1.0232 mL	2.5579 mL
	100 mM	0.0819 mL	0.4093 mL	0.8185 mL	2.0463 mL