1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Cimetidine sulfoxide

Cimetidine sulfoxide (Synonyms: Cimetidine sulphoxide)

Cat. No.: HY-136338
Handling Instructions

Cimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H2-receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment.

For research use only. We do not sell to patients.

Cimetidine sulfoxide Chemical Structure

Cimetidine sulfoxide Chemical Structure

CAS No. : 54237-72-8

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Description

Cimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H2-receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment[1].

IC50 & Target

Histamine H2-receptor[1]

In Vitro

Active transport of Cimetidine across the rat small intestine is observable at lower substrate concentrations (40 and 200 μM), but is masked by passive transfer at higher concentrations (400 μM). Cimetidine sulfoxide is detected after some incubations[2].

In Vivo

The enantiomeric composition of Cimetidine sulfoxide is also determined in rat urine (24 h) following the administration of Cimetidine (30 mg/kg; po) to male Wistar rats. The enantiomeric ratio in this case is found to be (+/−) 57:43[3].

Molecular Weight

268.34

Formula

C₁₀H₁₆N₆OS

CAS No.

54237-72-8

SMILES

O=S(CC/N=C(NC)/NC#N)CC1=C(C)N=CN1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Cimetidine sulfoxideCimetidine sulphoxideHistamine ReceptorCimetidinesulfoxidemetabolitepharmacokineticshaemodialysispepticulceroralintestineInhibitorinhibitorinhibit

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Cimetidine sulfoxide
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