1. Apoptosis
  2. MDM-2/p53
  3. Amifostine thiol

Amifostine thiol (Synonyms: WR-1065)

Cat. No.: HY-137864 Purity: >90.0%
Handling Instructions

Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine (HY-B0639). Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway.

For research use only. We do not sell to patients.

Amifostine thiol Chemical Structure

Amifostine thiol Chemical Structure

CAS No. : 31098-42-7

Size Price Stock Quantity
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine (HY-B0639). Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway[1][2][3].

IC50 & Target

p53[2]

In Vitro

Amifostine thiol can reduce both the direct and delayed detrimental effects of both high and low-LET radiation exposures[1].
Amifostine thiol attenuates both the DNA damage and the G1-phase arrest induced by radiation[1].
Amifostine thiol (4 mM; 30 minutes) protects RKO36 cells from chromosomal damage and death induced by ionizing radiation[1].
Amifostine thiol (4 mM; 30 minutes) protects irradiated RKO36 cells from delayed genomic instability[1].
Amifostine thiol is cytotoxic to RKO36 cells at milimolar concentrations, especially after continuous treatment[1].
Amifostine thiol at 40 μM protects RKO36 cells from delayed genomic instability but not from cell death and immediate chromosomal damage[1].
Amifostine thiol activates JNK resulting in the phosphorylation of p53 at threonine 81[2].
Amifostine thiol affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

134.24

Formula

C₅H₁₄N₂S

CAS No.

31098-42-7

SMILES

NCCCNCCS

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (1862.34 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.4493 mL 37.2467 mL 74.4934 mL
5 mM 1.4899 mL 7.4493 mL 14.8987 mL
10 mM 0.7449 mL 3.7247 mL 7.4493 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Amifostine thiolWR-1065WR1065WR 1065MDM-2/p53genomic instabilityamifostineradiationdelayed effectsradioprotectioncytoprotectiveInhibitorinhibitorinhibit

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Amifostine thiol
Cat. No.:
HY-137864
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