1. Apoptosis
    Metabolic Enzyme/Protease
  2. MDM-2/p53
    HIF/HIF Prolyl-Hydroxylase
  3. Amifostine

Amifostine  (Synonyms: WR2721)

Cat. No.: HY-B0639 Purity: ≥98.0%
COA Handling Instructions

Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action.

For research use only. We do not sell to patients.

Amifostine Chemical Structure

Amifostine Chemical Structure

CAS No. : 20537-88-6

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Solution
10 mM * 1 mL in Water USD 72 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 72 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 65 In-stock
Estimated Time of Arrival: December 31
50 mg USD 272 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Amifostine:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Amifostine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action[1][2][3][4].

In Vitro

Amifostine (0.78125-100 μM, 24 h) reduces tert-Butyl hydroperoxide (TBHP)-induced cell damage in a dose-dependent manner and significantly reduces H9c2 cells apoptosis at a concentration of 100 μM[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Amifostine (i.v., 400 mg/kg, 4 h) has a protective effect against myocardial I/R injury in male C57BL/6 mice[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice with myocardial I/R injury[5]
Dosage: 400 mg/kg
Administration: Intravenous injection; 4 hours
Result: Attenuated cardiomyocyte apoptosis and reduced the production of I/R-induced ROS.
Significantly reduced the expression of cleaved caspase 3 and Bax while enhanced the expression of SOD1, SOD2 and Bcl2.
Significantly increased SOD activity and reduced MDA levels.
Clinical Trial
Molecular Weight

214.22

Formula

C5H15N2O3PS

CAS No.
SMILES

OP(SCCNCCCN)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (466.81 mM; Need ultrasonic)

DMF : 1 mg/mL (4.67 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6681 mL 23.3405 mL 46.6810 mL
5 mM 0.9336 mL 4.6681 mL 9.3362 mL
10 mM 0.4668 mL 2.3340 mL 4.6681 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (466.81 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Product Name:
Amifostine
Cat. No.:
HY-B0639
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