2. Apoptosis Metabolic Enzyme/Protease
  3. MDM-2/p53 HIF/HIF Prolyl-Hydroxylase
  4. Amifostine

Amifostine  (Synonyms: WR2721)

Cat. No.: HY-B0639 Purity: ≥98.0%
COA Handling Instructions

Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action.

For research use only. We do not sell to patients.

Amifostine Chemical Structure

Amifostine Chemical Structure

CAS No. : 20537-88-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in Water USD 72 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 72 In-stock
Solid
5 mg USD 41 In-stock
10 mg USD 65 In-stock
50 mg USD 272 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Amifostine:

Amifostine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action[1][2][3][4].

In Vitro

Amifostine (0.78125-100?μM, 24 h) reduces tert-Butyl hydroperoxide (TBHP)-induced cell damage in a dose-dependent manner and significantly reduces H9c2 cells apoptosis at a concentration of 100 μM[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Amifostine Related Antibodies
In Vivo

Amifostine (i.v., 400 mg/kg, 4 h) has a protective effect against myocardial I/R injury in male C57BL/6 mice[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice with myocardial I/R injury[5]
Dosage: 400 mg/kg
Administration: Intravenous injection; 4 hours
Result: Attenuated cardiomyocyte apoptosis and reduced the production of I/R-induced ROS.
Significantly reduced the expression of cleaved caspase 3 and Bax while enhanced the expression of SOD1, SOD2 and Bcl2.
Significantly increased SOD activity and reduced MDA levels.
Clinical Trial
Molecular Weight

214.22

Appearance

Solid

Formula

C5H15N2O3PS
CAS No.
SMILES

OP(SCCNCCCN)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (466.81 mM; Need ultrasonic)

DMF : 1 mg/mL (4.67 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6681 mL 23.3405 mL 46.6810 mL
5 mM 0.9336 mL 4.6681 mL 9.3362 mL
10 mM 0.4668 mL 2.3340 mL 4.6681 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (466.81 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Amifostine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Amifostine20537-88-6WR2721WR 2721WR-2721MDM-2/p53HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHBroad-spectrumradioprotectorcytoprotectivethiolantiangiogenicHIF-α1p53DNA-damageInhibitorinhibitorinhibit

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