1. Apoptosis
    Metabolic Enzyme/Protease
  2. MDM-2/p53
    HIF/HIF Prolyl-Hydroxylase
  3. Amifostine

Amifostine (Synonyms: WR2721)

Cat. No.: HY-B0639 Purity: ≥98.0%
Handling Instructions

Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action.

For research use only. We do not sell to patients.

Amifostine Chemical Structure

Amifostine Chemical Structure

CAS No. : 20537-88-6

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in Water USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 65 In-stock
Estimated Time of Arrival: December 31
50 mg USD 272 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action[1][2][3][4].

Molecular Weight

214.22

Formula

C₅H₁₅N₂O₃PS

CAS No.

20537-88-6

SMILES

OP(SCCNCCCN)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (466.81 mM; Need ultrasonic)

DMF : 1 mg/mL (4.67 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6681 mL 23.3405 mL 46.6810 mL
5 mM 0.9336 mL 4.6681 mL 9.3362 mL
10 mM 0.4668 mL 2.3340 mL 4.6681 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

AmifostineWR2721WR 2721WR-2721MDM-2/p53HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHBroad-spectrumradioprotectorcytoprotectivethiolantiangiogenicHIF-α1p53DNA-damageInhibitorinhibitorinhibit

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Amifostine
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HY-B0639
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