2. Apoptosis Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase MDM-2/p53
  4. Amifostine sodium

Amifostine sodium (WR2721 sodium) is a phosphorus sulfate with radioprotective activity. Amifostine sodium can cause splenic vasodilation and may block autonomic ganglia. Amifostine sodium is clinically used to prevent cisplatin-induced ototoxicity.

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CAS No. : 59178-37-9

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Amifostine sodium Related Antibodies

Top Publications Citing Use of Products

    Amifostine sodium purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Feb 13;6(2):e70092.  [Abstract]

    The dynamics of the numbers of CFUs in the bone marrow from indicated groups within a month post‐irradiation. The results showed that the reduction in colony-forming unit (CFU) counts in mice treated with Amifostine (150 mg/kg; i.p.; single dose) was relatively mild at 7 days post-irradiation.

    Amifostine sodium purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Jan 31;23(1):58.  [Abstract]

    HE staining of testis among the control group, IR group, Amifostine (50 mg/kg; i.p.) group, NF-κB activator 2 group, and CU-T12-9 group.

    Amifostine sodium purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Jan 31;23(1):58.  [Abstract]

    Protein level alterations of Bclaf1, P-Rela, Rela, Sycp3, and β-actin were analyzed among the control group, IR group, Amifostine (50 mg/kg; i.p.) group, NF-κB activator 2 group, and CU-T12-9 group.

    Amifostine sodium purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Jan 31;23(1):58.  [Abstract]

    RT-qPCR analysis of Spliceosome-related gene expression levels across the control group, IR group, Amifostine (50 mg/kg; i.p.) group, NF-κB activator 2 group, and CU-T12-9 group.

    Amifostine sodium purchased from MedChemExpress. Usage Cited in: Bioact Mater.2024 May 21:39:191-205.  [Abstract]

    Cell viabilities of A31 cells under different doses of IR (0, 2, 4, 6, 8, and 10 Gy) with pretreatment of tFNAs, Amifostine (AMF, 54 μg/mL; 12 h), or nanosuit (250 nM; 12 h) (n = 5).

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    Description

    Amifostine sodium (WR2721 sodium) is a phosphorus sulfate with radioprotective activity. Amifostine sodium can cause splenic vasodilation and may block autonomic ganglia. Amifostine sodium is clinically used to prevent cisplatin-induced ototoxicity[1].

    Molecular Weight

    258.19

    Formula

    C5H13N2Na2O3PS
    CAS No.
    SMILES

    O=P(SCCNCCCN)(O[Na])O[Na]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Amifostine sodium Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Amifostine59178-37-9WR2721WR 2721WR-2721HIF/HIF Prolyl-HydroxylaseMDM-2/p53Hypoxia-inducible factorsHIFsHIF-PHBroad-spectrumradioprotectorcytoprotectivethiolantiangiogenicHIF-α1p53DNA-damageInhibitorinhibitorinhibit

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