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Amifostine sodium

(Synonyms: WR2721 sodium)
13 Cited Publications
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Based on 13 publication(s) in Google Scholar

Amifostine sodium (WR2721 sodium) is a phosphorus sulfate with radioprotective activity. Amifostine sodium can cause splenic vasodilation and may block autonomic ganglia. Amifostine sodium is clinically used to prevent cisplatin-induced ototoxicity.

For research use only. We do not sell to patients.

  • CAS No.: 59178-37-9
  • Formula: C5H13N2Na2O3PS
  • Molecular Weight:258.19
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Amifostine sodium Chemical Structure
    Amifostine sodium Chemical Structure
  • Experimental Validation Results for Amifostine sodium
  • Experimental Validation Results for Amifostine sodium
  • Experimental Validation Results for Amifostine sodium
  • Experimental Validation Results for Amifostine sodium
  • Experimental Validation Results for Amifostine sodium
CAS No.: 59178-37-9
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Cell Proliferation/Viability AssayIn Vivo Efficacy StudyHistological Imaging/StainingWBRT-PCR
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  • Amifostine sodium Chemical Structure
    Amifostine sodium Chemical Structure
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    Amifostine sodium purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Feb 13;6(2):e70092. [Abstract]

    Customer Validation
     The dynamics of the numbers of CFUs in the bone marrow from indicated groups within a month post‐irradiation. The results showed that the reduction in colony-forming unit (CFU) counts in mice treated with Amifostine (150 mg/kg; i.p.; single dose) was relatively mild at 7 days post-irradiation.

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    Amifostine sodium purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Jan 31;23(1):58. [Abstract]

    Customer Validation
     HE staining of testis among the control group, IR group, Amifostine (50 mg/kg; i.p.) group, NF-κB activator 2 group, and CU-T12-9 group.

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    Amifostine sodium purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Jan 31;23(1):58. [Abstract]

    Customer Validation
     Protein level alterations of Bclaf1, P-Rela, Rela, Sycp3, and β-actin were analyzed among the control group, IR group, Amifostine (50 mg/kg; i.p.) group, NF-κB activator 2 group, and CU-T12-9 group.

  • 1/16

    Amifostine sodium purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Jan 31;23(1):58. [Abstract]

    Customer Validation
     RT-qPCR analysis of Spliceosome-related gene expression levels across the control group, IR group, Amifostine (50 mg/kg; i.p.) group, NF-κB activator 2 group, and CU-T12-9 group.

  • 1/16

    Amifostine sodium purchased from MedChemExpress. Usage Cited in: Bioact Mater.2024 May 21:39:191-205. [Abstract]

    Customer Validation
     Cell viabilities of A31 cells under different doses of IR (0, 2, 4, 6, 8, and 10 Gy) with pretreatment of tFNAs, Amifostine (AMF, 54 μg/mL; 12 h), or nanosuit (250 nM; 12 h) (n = 5).

  • Amifostine sodium