1. Apoptosis
    Metabolic Enzyme/Protease
  2. MDM-2/p53
    HIF/HIF Prolyl-Hydroxylase
  3. Amifostine trihydrate

Amifostine trihydrate (Synonyms: WR2721 trihydrate)

Cat. No.: HY-B0639A
Handling Instructions

Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action.

For research use only. We do not sell to patients.

Amifostine trihydrate Chemical Structure

Amifostine trihydrate Chemical Structure

CAS No. : 112901-68-5

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Description

Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action[1][2][3][4].

Clinical Trial
Molecular Weight

284.27

Formula

C₅H₂₁N₂O₇PS

CAS No.

112901-68-5

SMILES

NCCCNCC(OP(O)(O)=O)S.[H]O[H].[H]O[H].[H]O[H]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AmifostineWR2721WR 2721WR-2721MDM-2/p53HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHBroad-spectrumradioprotectorcytoprotectivethiolantiangiogenicHIF-α1p53DNA-damageInhibitorinhibitorinhibit

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Amifostine trihydrate
Cat. No.:
HY-B0639A
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