112901-68-5
Chemical Structure
Amifostine trihydrate
Synonym(s): WR2721 trihydrate
- CAS No.: 112901-68-5
- Formula:C5H21N2O6PS
- Molecular Weight:268.27
IUPAC Name: S-(2-((3-aminopropyl)amino)ethyl) O,O-dihydrogen phosphorothioate trihydrate
InChIKey: TXQPXJKRNHJWAX-UHFFFAOYSA-N
SMILES: OP(SCCNCCCN)(O)=O.[H]O[H].[H]O[H].[H]O[H]
Biological Activity: Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action[1][2][3][4].
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Amifostine trihydrate | 99.95% | Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action. | ||||||||||||||||||||
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Similarity Score 0.93
HY-B0639Amifostine -
Similarity Score 0.81
HY-105429WR 151327 -
Similarity Score 0.78
HY-B0639CAmifostine sodium -
Similarity Score 0.70
HY-113203APutreanine dihydrochloride -
Similarity Score 0.70
HY-W141781Cysteamine S-phosphate sodium -
Similarity Score 0.70
HY-137864Amifostine thiol -
Similarity Score 0.70
HY-103640RAmifostine thiol dihydrochloride (Standard) -
Similarity Score 0.68
HY-B1776ARSpermidine hydrochloride (Standard) -
Similarity Score 0.68
HY-B1776AS1Spermidine-13C4 hydrochloride -
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References
- [1]. D Maurici, et al. Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene. 2001 Jun 14;20(27):3533-40. [Content Brief]
- [2]. Efstathia Giannopoulou, et al. Amifostine inhibits angiogenesis in vivo. J Pharmacol Exp Ther. 2003 Feb;304(2):729-37. [Content Brief]
- [3]. Michael I Koukourakis, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004 Jan;53(1):8-14. [Content Brief]
- [4]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47. [Content Brief]
