1. Others
    Metabolic Enzyme/Protease
  2. Thyroid Hormone Receptor
    Drug Metabolite
    Endogenous Metabolite
  3. Thyroxine sulfate

Thyroxine sulfate (Synonyms: T4 Sulfate)

Cat. No.: HY-101406 Purity: >98.0%
Handling Instructions

Thyroxine sulfate is a thyroid hormone metabolite.

For research use only. We do not sell to patients.

Thyroxine sulfate Chemical Structure

Thyroxine sulfate Chemical Structure

CAS No. : 77074-49-8

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5 mg USD 96 Ask For Quote & Lead Time
10 mg USD 144 Ask For Quote & Lead Time

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Description

Thyroxine sulfate is a thyroid hormone metabolite.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Thyroxine sulfate (T4S) is a normal component of human serum and amniotic fluid, and it is mostly derived from thyroxine peripherally and accumulates when type I 5-monodeiodinating activity is low in fetuses or inhibited by drugs, such as ipodate[1].

In Vivo

Significant amounts of thyroxine sulfate (T4S) in fetal sheep serum, meconium, bile, and amniotic and allantoic fluids are observed. T4S concentration in amniotic fluid from women at 18-19 weeks of gestation (25.5 ng/dL) is higher than that at 14-15 weeks of gestation (14.3 ng/dL). A significant rise in serum T4S is detected in hyperthyroid patients 1 day after ingestion of 1 g of ipodate[1]. Thyroxine undergoes significant sulfation in rats, and biliary excretion of T4S is enhanced if its type I deiodination is inhibited[2]. Serum T4S levels are clearly elevated compared with healthy references, and the decreased deiodination by liver D1 during critical illness appears to play a role in this increase in serum T4S levels[3].

Molecular Weight

856.93

Formula

C₁₅H₁₁I₄NO₇S

CAS No.

77074-49-8

SMILES

N[[email protected]@H](CC1=CC(I)=C(C(I)=C1)OC2=CC(I)=C(OS(=O)(O)=O)C(I)=C2)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (36.18 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1670 mL 5.8348 mL 11.6696 mL
5 mM 0.2334 mL 1.1670 mL 2.3339 mL
10 mM 0.1167 mL 0.5835 mL 1.1670 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.58 mg/mL (3.01 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.58 mg/mL (3.01 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.58 mg/mL (3.01 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ThyroxineT4 SulfateThyroid Hormone ReceptorDrug MetaboliteEndogenous MetaboliteTHRInhibitorinhibitorinhibit

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Thyroxine sulfate
Cat. No.:
HY-101406
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