1. Others
    Metabolic Enzyme/Protease
  2. Thyroid Hormone Receptor
    Drug Metabolite
    Endogenous Metabolite
  3. Thyroxine sulfate

Thyroxine sulfate (Synonyms: T4 Sulfate)

Cat. No.: HY-101406 Purity: >98.0%
Handling Instructions

Thyroxine sulfate is a thyroid hormone metabolite.

For research use only. We do not sell to patients.

Thyroxine sulfate Chemical Structure

Thyroxine sulfate Chemical Structure

CAS No. : 77074-49-8

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10 mg USD 144 Ask For Quote & Lead Time

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Other Forms of Thyroxine sulfate:

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Description

Thyroxine sulfate is a thyroid hormone metabolite.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Thyroxine sulfate (T4S) is a normal component of human serum and amniotic fluid, and it is mostly derived from thyroxine peripherally and accumulates when type I 5-monodeiodinating activity is low in fetuses or inhibited by drugs, such as ipodate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Significant amounts of thyroxine sulfate (T4S) in fetal sheep serum, meconium, bile, and amniotic and allantoic fluids are observed. T4S concentration in amniotic fluid from women at 18-19 weeks of gestation (25.5 ng/dL) is higher than that at 14-15 weeks of gestation (14.3 ng/dL). A significant rise in serum T4S is detected in hyperthyroid patients 1 day after ingestion of 1 g of ipodate[1]. Thyroxine undergoes significant sulfation in rats, and biliary excretion of T4S is enhanced if its type I deiodination is inhibited[2]. Serum T4S levels are clearly elevated compared with healthy references, and the decreased deiodination by liver D1 during critical illness appears to play a role in this increase in serum T4S levels[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

856.93

Formula

C₁₅H₁₁I₄NO₇S

CAS No.

77074-49-8

SMILES

N[[email protected]@H](CC1=CC(I)=C(C(I)=C1)OC2=CC(I)=C(OS(=O)(O)=O)C(I)=C2)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (36.18 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1670 mL 5.8348 mL 11.6696 mL
5 mM 0.2334 mL 1.1670 mL 2.3339 mL
10 mM 0.1167 mL 0.5835 mL 1.1670 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.58 mg/mL (3.01 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.58 mg/mL (3.01 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.58 mg/mL (3.01 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ThyroxineT4 SulfateThyroid Hormone ReceptorDrug MetaboliteEndogenous MetaboliteTHRInhibitorinhibitorinhibit

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Product Name:
Thyroxine sulfate
Cat. No.:
HY-101406
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