1. Steroids

5α-Pregnane-3β,6α-diol-20-one 

Cat. No.: HY-109564 Purity: >98.0%
Handling Instructions

5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.

For research use only. We do not sell to patients.

5α-Pregnane-3β,6α-diol-20-one Chemical Structure

5α-Pregnane-3β,6α-diol-20-one Chemical Structure

CAS No. : 21853-11-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 660 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.

In Vitro

Progesterone is converted to 5α-pregnane-3β,6α-diol-20-one in human fibroblasts[1]. Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β,6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β,6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather relies on 3β-HSD activity[2].

References
Molecular Weight

334.49

Formula

C₂₁H₃₄O₃

CAS No.

21853-11-2

SMILES

C[[email protected]@]12[[email protected]]3([H])[[email protected]](C[[email protected]](O)[[email protected]@]1([H])C[[email protected]@H](O)CC2)([H])[[email protected]@]4([H])[[email protected]@](C)([[email protected]@H](C(C)=O)CC4)CC3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
5α-Pregnane-3β,6α-diol-20-one
Cat. No.:
HY-109564
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5α-Pregnane-3β,6α-diol-20-one

Cat. No.: HY-109564