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Cat. No.: HY-N7177

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Hydroxytanshinone IIA

Name: Hydroxytanshinone IIA
Brand: MedChemExpress
SKU: HY-N7177
Price: 484.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Hydroxytanshinone IIA is a hydrolytic metabolite of Tanshinone IIA (HY-N0135). Tanshinone IIA inhibits angiogenesis by targeting the protein kinase domain of VEGF/VEGFR2. Hydroxytanshinone IIA exhibits antioxidant and anti-inflammatory activities. Hydroxytanshinone IIA can be used in studies of angina pectoris and myocardial infarction.

For research use only. We do not sell to patients.

Purity : 99.83%
CAS No.: 18887-18-8
Formula: C₁₉H₁₈O₄
Molecular Weight:310.34

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Hydroxytanshinone IIA Chemical Structure

CAS No.: 18887-18-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All VEGFR Isoforms :

In Vitro

The formation of Hydroxytanshinone IIA from Tanshinone IIA (HY-N0135) in rat liver microsomes exhibits sigmoidal kinetic characteristics^[1].
The designated molar mass of Hydroxytanshinone IIA is 310^[2].
Hydroxytanshinone IIA exhibits a characteristic elution profile at 25.7 min under LC gradient 1, and shows a characteristic fragmentation pattern dominated by the dehydrated protonated ion at m/z 293 under the specified LC-MS/MS conditions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 18887-18-8
Appearance Solid
Molecular Weight 310.34
Formula C₁₉H₁₈O₄
Color Brown to reddish brown
SMILES

O=C(C1=C2C=CC3=C1C(O)CCC3(C)C)C(C4=C2OC=C4C)=O
Structure Classification
- Quinones
- Naphthalene Quinones
Initial Source
- Plants
- Labiatae
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (292 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li P, et al. Simultaneous determination of tanshinone IIA and its three hydroxylated metabolites by liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2006;20(5):815-22. [Content Brief]

[2]. Li P, et al. Characterization of metabolites of tanshinone IIA in rats by liquid chromatography/tandem mass spectrometry. Journal of mass spectrometry : JMS. 2006 May;41(5):670-84.

[3]. Li P, et al. Identification of tanshinone IIA metabolites in rat liver microsomes by liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2006 Feb 03;1104(1-2):366-9.

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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