1. Cell Cycle/DNA Damage
    Epigenetics
    Apoptosis
  2. HDAC
    Apoptosis
  3. Chlamydocin

Chlamydocin 

Cat. No.: HY-P2228
Handling Instructions

Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3.

For research use only. We do not sell to patients.

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Chlamydocin Chemical Structure

Chlamydocin Chemical Structure

CAS No. : 53342-16-8

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Description

Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3[1].

IC50 & Target[1]

HDAC

1.3 nM (IC50)

In Vitro

Chlamydocin is originally isolated from the fungus Diheterospora chlamydosporia. Chlamydocin exhibits a broad spectrum of antiproliferative activity toward various cancer cell lines, irrespective of their p53 status. The antiproliferative activity of Chlamydocin is accompanied by accumulation of hyperacetylated histones H3 and H4, induction of p21cip1/waf1, and accumulation of cells in G2/M phase of the cell cycle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

526.62

Formula

C₂₈H₃₈N₄O₆

CAS No.

53342-16-8

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ChlamydocinHDACApoptosisHistone deacetylasescyclictetrapeptidaccumulationhyperacetylatedhistonesH3H4A2780ovariancancercellsInhibitorinhibitorinhibit

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Chlamydocin
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