1. Cell Cycle/DNA Damage
  2. HDAC
  3. SS-208


Cat. No.: HY-126330 Purity: 98.13%
COA Handling Instructions

SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma.

For research use only. We do not sell to patients.

SS-208 Chemical Structure

SS-208 Chemical Structure

CAS No. : 2245942-72-5

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Free Sample (0.1 - 0.5 mg)   Apply Now  
5 mg USD 290 In-stock
10 mg USD 480 In-stock
25 mg USD 900 In-stock
50 mg USD 1450 In-stock
100 mg USD 2200 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma[1].

IC50 & Target[1]


12 nM (IC50)


1.23 μM (IC50)


1.39 μM (IC50)


5.12 μM (IC50)


6.91 μM (IC50)


8.34 μM (IC50)

In Vivo

SS-208 (25 mg/kg, ip) significantly reduces the tumor growth in melanoma murine model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice injected immunogenic murine SM1 melanoma cells subcutaneously[1].
Dosage: 25 mg/kg.
Administration: IP on day 4, 7, 12, 15 and 18.
Result: Significantly reduced the tumor growth.
Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (363.21 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9057 mL 14.5285 mL 29.0571 mL
5 mM 0.5811 mL 2.9057 mL 5.8114 mL
10 mM 0.2906 mL 1.4529 mL 2.9057 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.04 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.04 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.04 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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