1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. SS-208

SS-208 

Cat. No.: HY-126330 Purity: 98.13%
Handling Instructions

SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma.

For research use only. We do not sell to patients.

SS-208 Chemical Structure

SS-208 Chemical Structure

CAS No. : 2245942-72-5

Size Price Stock Quantity
5 mg USD 290 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
25 mg USD 900 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma[1].

IC50 & Target[1]

HDAC6

12 nM (IC50)

HDAC8

1.23 μM (IC50)

HDAC1

1.39 μM (IC50)

HDAC11

5.12 μM (IC50)

HDAC5

6.91 μM (IC50)

HDAC7

8.34 μM (IC50)

In Vivo

SS-208 (25 mg/kg, ip) significantly reduces the tumor growth in melanoma murine model[1].

Animal Model: C57BL/6 mice injected immunogenic murine SM1 melanoma cells subcutaneously[1].
Dosage: 25 mg/kg.
Administration: IP on day 4, 7, 12, 15 and 18.
Result: Significantly reduced the tumor growth.
Molecular Weight

344.15

Formula

C₁₃H₁₁Cl₂N₃O₄

CAS No.

2245942-72-5

SMILES

O=C(C1=NOC(CCNC(C2=CC=C(Cl)C(Cl)=C2)=O)=C1)NO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (363.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9057 mL 14.5285 mL 29.0571 mL
5 mM 0.5811 mL 2.9057 mL 5.8114 mL
10 mM 0.2906 mL 1.4529 mL 2.9057 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.04 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.04 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.04 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SS-208SS208SS 208HDACHistone deacetylasesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SS-208
Cat. No.:
HY-126330
Quantity:
MCE Japan Authorized Agent: