1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. SS-208

SS-208 

Cat. No.: HY-126330
Handling Instructions

SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma.

For research use only. We do not sell to patients.

SS-208 Chemical Structure

SS-208 Chemical Structure

CAS No. : 2245942-72-5

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Description

SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma[1].

IC50 & Target[1]

HDAC6

12 nM (IC50)

HDAC8

1.23 μM (IC50)

HDAC1

1.39 μM (IC50)

HDAC11

5.12 μM (IC50)

HDAC5

6.91 μM (IC50)

HDAC7

8.34 μM (IC50)

In Vivo

SS-208 (25 mg/kg, ip) significantly reduces the tumor growth in melanoma murine model[1].

Animal Model: C57BL/6 mice injected immunogenic murine SM1 melanoma cells subcutaneously[1].
Dosage: 25 mg/kg.
Administration: IP on day 4, 7, 12, 15 and 18.
Result: Significantly reduced the tumor growth.
Molecular Weight

344.15

Formula

C₁₃H₁₁Cl₂N₃O₄

CAS No.

2245942-72-5

SMILES

O=C(C1=NOC(CCNC(C2=CC=C(Cl)C(Cl)=C2)=O)=C1)NO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SS-208SS208SS 208HDACHistone deacetylasesInhibitorinhibitorinhibit

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