1-Methylhistamine-d₃ dihydrochloride

Cat. No.: HY-W053787S Pureza: 99.91%: Ficha de datos
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1-Methylhistamine-d₃ (dihydrochloride) is the deuterium labeled 1-Methylhistamine (dihydrochloride). 1-Methylhistamine dihydrochloride is a histamine metabolite.

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1-Methylhistamine-d<sub>3</sub> dihydrochloride

1-Methylhistamine-d₃ dihydrochloride Estructura química

No. CAS : 344299-49-6

Tamaño	Stock	Cantidad
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	Obtener un presupuesto
50 mg	Obtener un presupuesto

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Other Forms of 1-Methylhistamine-d₃ dihydrochloride:

1-Methylhistamine dihydrochloride In-stock
1-Methylhistamine Obtener un presupuesto

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Descripciòn

1-Methylhistamine-d₃ (dihydrochloride) is the deuterium labeled 1-Methylhistamine (dihydrochloride)^[1]. 1-Methylhistamine dihydrochloride is a histamine metabolite^[2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

201.11

Fòrmula

C₆H₁₀D₃Cl₂N₃

No. CAS

344299-49-6

Unlabeled CAS

501-75-7

Appearance

Solid

Color

White to off-white

SMILES

NCCC1=CN(C([2H])([2H])[2H])C=N1.Cl.Cl

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvente y solubilidad

In Vitro:

H2O : 62.5 mg/mL (310.78 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.9724 mL	24.8620 mL	49.7240 mL
5 mM	0.9945 mL	4.9724 mL	9.9448 mL
10 mM	0.4972 mL	2.4862 mL	4.9724 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 99.91%

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Ficha de datos (271 KB) SDS (252 KB)

COA (248 KB) HNMR (770 KB) RP-HPLC (286 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Saito K, et al. Determination of urinary excretion of histamine and 1-methylhistamine by liquid chromatography. J Chromatogr B Biomed Appl. 1994 Apr 1;654(2):270-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O	1 mM	4.9724 mL	24.8620 mL	49.7240 mL	124.3101 mL
	5 mM	0.9945 mL	4.9724 mL	9.9448 mL	24.8620 mL
	10 mM	0.4972 mL	2.4862 mL	4.9724 mL	12.4310 mL
	15 mM	0.3315 mL	1.6575 mL	3.3149 mL	8.2873 mL
	20 mM	0.2486 mL	1.2431 mL	2.4862 mL	6.2155 mL
	25 mM	0.1989 mL	0.9945 mL	1.9890 mL	4.9724 mL
	30 mM	0.1657 mL	0.8287 mL	1.6575 mL	4.1437 mL
	40 mM	0.1243 mL	0.6216 mL	1.2431 mL	3.1078 mL
	50 mM	0.0994 mL	0.4972 mL	0.9945 mL	2.4862 mL
	60 mM	0.0829 mL	0.4144 mL	0.8287 mL	2.0718 mL
	80 mM	0.0622 mL	0.3108 mL	0.6216 mL	1.5539 mL
	100 mM	0.0497 mL	0.2486 mL	0.4972 mL	1.2431 mL