1-Methylhistamine-d3 dihydrochloride
Based on 1 Customer Validation
1-Methylhistamine-d3 (dihydrochloride) is the deuterium labeled 1-Methylhistamine (dihydrochloride). 1-Methylhistamine dihydrochloride is a histamine metabolite.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 344299-49-6
- Formula: C6H10D3Cl2N3
- Molecular Weight:201.11
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 344299-49-6
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Unlabeled Cas 501-75-7
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Appearance Solid
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Molecular Weight 201.11
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Formula C6H10D3Cl2N3
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Color White to off-white
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SMILES
NCCC1=CN(C([2H])([2H])[2H])C=N1.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
H2O : 62.5 mg/mL (310.78 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Saito K, et al. Determination of urinary excretion of histamine and 1-methylhistamine by liquid chromatography. J Chromatogr B Biomed Appl. 1994 Apr 1;654(2):270-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.9724 mL | 24.8620 mL | 49.7240 mL | 124.3101 mL |
| 5 mM | 0.9945 mL | 4.9724 mL | 9.9448 mL | 24.8620 mL | |
| 10 mM | 0.4972 mL | 2.4862 mL | 4.9724 mL | 12.4310 mL | |
| 15 mM | 0.3315 mL | 1.6575 mL | 3.3149 mL | 8.2873 mL | |
| 20 mM | 0.2486 mL | 1.2431 mL | 2.4862 mL | 6.2155 mL | |
| 25 mM | 0.1989 mL | 0.9945 mL | 1.9890 mL | 4.9724 mL | |
| 30 mM | 0.1657 mL | 0.8287 mL | 1.6575 mL | 4.1437 mL | |
| 40 mM | 0.1243 mL | 0.6216 mL | 1.2431 mL | 3.1078 mL | |
| 50 mM | 0.0994 mL | 0.4972 mL | 0.9945 mL | 2.4862 mL | |
| 60 mM | 0.0829 mL | 0.4144 mL | 0.8287 mL | 2.0718 mL | |
| 80 mM | 0.0622 mL | 0.3108 mL | 0.6216 mL | 1.5539 mL | |
| 100 mM | 0.0497 mL | 0.2486 mL | 0.4972 mL | 1.2431 mL |
1-Methylhistamine-d3 dihydrochloride Related Classifications
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