1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. MJ33-OH

MJ33-OH 

Cat. No.: HY-129944
Handling Instructions

MJ33-OH is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6.

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MJ33-OH Chemical Structure

MJ33-OH Chemical Structure

CAS No. : 199106-13-3

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Description

MJ33-OH is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6[1].

In Vivo

MJ33 (0.5 μM/kg; by tail vein, at 24 h before MCAO) significantly blocks the increase IL-1β, IL-17 and IL-23 in rats stimulated by Prdx6 siRNA treatment[2].
Compared with the Prdx6 siRNA group, combined exposure to Prdx6 siRNA and MJ33 significantly downregulates the mRNA and protein expression of NF-κB, iNOS and COX-2[2].

Molecular Weight

508.55

Formula

C₂₂H₄₄F₃O₇P

CAS No.

199106-13-3

SMILES

O=P(OCO)(O)OC(COCCCCCCCCCCCCCCCC)COCC(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MJ33-OHPhospholipasePrdx6-iPLA2activityinflammationcompetitiveactive-site-directedcalciumindependentdipalmitoylphosphatidylcholineinflammatoryInhibitorinhibitorinhibit

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MJ33-OH
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HY-129944
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