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  4. Sulfobromophthalein disodium salt

Sulfobromophthalein disodium salt  (Synonyms: Bromosulfophthalein disodium salt)

Cat. No.: HY-D0217 Purity: 99.77%
COA
SDS
Handling Instructions Technical Support

Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of agents and metabolites.

For research use only. We do not sell to patients.

Sulfobromophthalein disodium salt

Sulfobromophthalein disodium salt Chemical Structure

CAS No. : 71-67-0

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10 mM * 1 mL in DMSO
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Customer Review

Based on 4 publication(s) in Google Scholar

Sulfobromophthalein disodium salt Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of agents and metabolites[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
0.05 μM
Compound: Bromosulfophthalein
TP_TRANSPORTER: inhibition of Phalloidin uptake (Phalloidin: 1 uM) in OATP-C-expressing HEK293 cells
TP_TRANSPORTER: inhibition of Phalloidin uptake (Phalloidin: 1 uM) in OATP-C-expressing HEK293 cells
[PMID: 14530907]
HeLa IC50
7.3 μM
Compound: Bromosulfophthalein
TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cells
TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cells
[PMID: 10565843]
In Vitro

Sulfobromophthalein disodium salt is a synthetic dye introduced in 1925 as a clinical tool aiming at the assessment of the liver function[1].
Sulfobromophthalein (BSP) is a pH indicator dye, featured by fast (17), protondependent quinoidal–phenolic tautomerism (pK = 8.5) [1].
Bromosulfalein has been commonly used as both a substrate and inhibitor of organic anionic transporting polypeptide 1B1 (OATP1B1), OATP1B3, OATP1A2, and OATP2B1, as well as multidrug resistance protein 2 (MDR2) [2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfobromophthalein disodium salt Related Antibodies
Molecular Weight

838.00

Formula

C20H8Br4Na2O10S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1OC(C2=CC(S(=O)(O[Na])=O)=C(O)C=C2)(C3=CC(S(=O)(O[Na])=O)=C(O)C=C3)C4=C1C(Br)=C(Br)C(Br)=C4Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (298.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1933 mL 5.9666 mL 11.9332 mL
5 mM 0.2387 mL 1.1933 mL 2.3866 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.77%

SDS (419 KB)

COA (265 KB) HNMR (275 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1933 mL 5.9666 mL 11.9332 mL 29.8329 mL
5 mM 0.2387 mL 1.1933 mL 2.3866 mL 5.9666 mL
10 mM 0.1193 mL 0.5967 mL 1.1933 mL 2.9833 mL
15 mM 0.0796 mL 0.3978 mL 0.7955 mL 1.9889 mL
20 mM 0.0597 mL 0.2983 mL 0.5967 mL 1.4916 mL
25 mM 0.0477 mL 0.2387 mL 0.4773 mL 1.1933 mL
30 mM 0.0398 mL 0.1989 mL 0.3978 mL 0.9944 mL
40 mM 0.0298 mL 0.1492 mL 0.2983 mL 0.7458 mL
50 mM 0.0239 mL 0.1193 mL 0.2387 mL 0.5967 mL
60 mM 0.0199 mL 0.0994 mL 0.1989 mL 0.4972 mL
80 mM 0.0149 mL 0.0746 mL 0.1492 mL 0.3729 mL
100 mM 0.0119 mL 0.0597 mL 0.1193 mL 0.2983 mL
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Sulfobromophthalein disodium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfobromophthalein disodium71-67-0Bromosulfophthalein disodiumFluorescent DyeBSPOATP1BMDR2Inhibitorinhibitorinhibit

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