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  2. Sulfobromophthalein disodium salt

Sulfobromophthalein disodium salt (Synonyms: Bromosulfophthalein disodium salt)

Cat. No.: HY-D0217
Handling Instructions

Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of drugs and metabolites.

For research use only. We do not sell to patients.

Sulfobromophthalein disodium salt Chemical Structure

Sulfobromophthalein disodium salt Chemical Structure

CAS No. : 71-67-0

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Estimated Time of Arrival: December 31
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Description

Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of drugs and metabolites[1].

In Vitro

Sulfobromophthalein disodium salt is a synthetic dye introduced in 1925 as a clinical tool aiming at the assessment of the liver function[1].
Sulfobromophthalein (BSP) is a pH indicator dye, featured by fast (17), protondependent quinoidal–phenolic tautomerism (pK = 8.5) [1].
Bromosulfalein has been commonly used as both a substrate and inhibitor of organic anionic transporting polypeptide 1B1 (OATP1B1), OATP1B3, OATP1A2, and OATP2B1, as well as multidrug resistance protein 2 (MDR2) [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

838.00

Formula

C₂₀H₈Br₄Na₂O₁₀S₂

CAS No.

71-67-0

SMILES

O=C1OC(C2=CC(S(=O)(O[Na])=O)=C(O)C=C2)(C3=CC(S(=O)(O[Na])=O)=C(O)C=C3)C4=C1C(Br)=C(Br)C(Br)=C4Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 500 mg/mL (596.66 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1933 mL 5.9666 mL 11.9332 mL
5 mM 0.2387 mL 1.1933 mL 2.3866 mL
10 mM 0.1193 mL 0.5967 mL 1.1933 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 4.17 mg/mL (4.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 4.17 mg/mL (4.98 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 4.17 mg/mL (4.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Keywords:

Sulfobromophthalein disodiumBromosulfophthalein disodiumOthersBSPOATP1BMDR2Inhibitorinhibitorinhibit

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Sulfobromophthalein disodium salt
Cat. No.:
HY-D0217
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