Sulfobromophthalein disodium salt
Based on 6 publication(s) in Google Scholar
Sulfobromophthalein (Bromosulfophthalein) disodium salt is an organic anion dye used in the study of a variety of membrane carriers expressed in animal tissues and involved in transport of agents and metabolites.
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 71-67-0
- Formula: C20H8Br4Na2O10S2
- Molecular Weight:838.00
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Sulfobromophthalein disodium salt
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.05 μM
Compound: Bromosulfophthalein
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TP_TRANSPORTER: inhibition of Phalloidin uptake (Phalloidin: 1 uM) in OATP-C-expressing HEK293 cells
TP_TRANSPORTER: inhibition of Phalloidin uptake (Phalloidin: 1 uM) in OATP-C-expressing HEK293 cells
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[PMID: 14530907] |
| HeLa | IC50 |
7.3 μM
Compound: Bromosulfophthalein
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TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cells
TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cells
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[PMID: 10565843] |
Sulfobromophthalein disodium salt is a synthetic dye introduced in 1925 as a clinical tool aiming at the assessment of the liver function[1].
Sulfobromophthalein (BSP) is a pH indicator dye, featured by fast (17), protondependent quinoidal–phenolic tautomerism (pK = 8.5) [1].
Bromosulfalein has been commonly used as both a substrate and inhibitor of organic anionic transporting polypeptide 1B1 (OATP1B1), OATP1B3, OATP1A2, and OATP2B1, as well as multidrug resistance protein 2 (MDR2) [2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 71-67-0
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Appearance Solid
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Molecular Weight 838.00
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Formula C20H8Br4Na2O10S2
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Color White to off-white
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SMILES
O=C1OC(C2=CC(S(=O)(O[Na])=O)=C(O)C=C2)(C3=CC(S(=O)(O[Na])=O)=C(O)C=C3)C4=C1C(Br)=C(Br)C(Br)=C4Br
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Synonyms
Bromosulfophthalein disodium salt
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (6)
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Journal Impact Factor
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Most Recent
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Biomater Res
Image-Guided Monitoring of Mitochondria and Blood-Brain Barrier Dysfunction in Amyotrophic Lateral Sclerosis Mice. [Abstract]2025 Mar 17:29:0162. PMID: 40099231 -
Eur J Med Chem
A novel ICG-labeled cyclic TMTP1 peptide dimer for sensitive tumor imaging and enhanced photothermal therapy in vivo. [Abstract]2022 Jan 5:227:113935. PMID: 34731764 -
Mol Diagn Ther
Real-Time Detection of Colorectal Cancer Using Topical Application of a pH-Activatable Fluorophore. [Abstract]2026 Jul;30(4):689-706. PMID: 42174369 -
ACS Omega
In Vivo Evaluation of a Gallium-68-Labeled Tumor-Tracking Cyanine Dye for Positron Emission Tomography/Near-Infrared Fluorescence Carcinoma Imaging, Image-Guided Surgery, and Photothermal Therapy. [Abstract]2023 Feb 3;8(6):6067-6077. PMID: 36816684 -
bioRxiv
Cortisol Drives Pregnancy-Associated Induction of Hepatic OAT2, NTCP, and OCT1 in HepaRG cells Through GR-, HNF1α-, and HNF4α-Dependent Signaling. [Abstract]2026 Jun 19:2026.06.15.732466. PMID: 42367899 -
Solvent & Solubility
DMSO : 250 mg/mL (298.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (284 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1933 mL | 5.9666 mL | 11.9332 mL | 29.8329 mL |
| 5 mM | 0.2387 mL | 1.1933 mL | 2.3866 mL | 5.9666 mL | |
| 10 mM | 0.1193 mL | 0.5967 mL | 1.1933 mL | 2.9833 mL | |
| 15 mM | 0.0796 mL | 0.3978 mL | 0.7955 mL | 1.9889 mL | |
| 20 mM | 0.0597 mL | 0.2983 mL | 0.5967 mL | 1.4916 mL | |
| 25 mM | 0.0477 mL | 0.2387 mL | 0.4773 mL | 1.1933 mL | |
| 30 mM | 0.0398 mL | 0.1989 mL | 0.3978 mL | 0.9944 mL | |
| 40 mM | 0.0298 mL | 0.1492 mL | 0.2983 mL | 0.7458 mL | |
| 50 mM | 0.0239 mL | 0.1193 mL | 0.2387 mL | 0.5967 mL | |
| 60 mM | 0.0199 mL | 0.0994 mL | 0.1989 mL | 0.4972 mL | |
| 80 mM | 0.0149 mL | 0.0746 mL | 0.1492 mL | 0.3729 mL | |
| 100 mM | 0.0119 mL | 0.0597 mL | 0.1193 mL | 0.2983 mL |
Sulfobromophthalein disodium salt Related Classifications
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