Pteridine-2,4(1H,3H)-dione
Based on 1 Customer Validation
Pteridine-2,4 (1H,3H)-dione is a pteridine derivative (xanthopterin) and a sulfur-containing pteridine compound (2,4-dimercaptopyrimidine). Pteridine-2,4 (1H,3H)-dione possesses metal-binding ability, and forms closed-shell (ionic) interactions with palladium via sulfur and nitrogen atoms. Pteridine-2,4 (1H,3H)-dione derivates can be used in studies related to neuroblastoma, glioma and breast cancer.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 487-21-8
- Formula: C6H4N4O2
- Molecular Weight:164.12
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-W037619R
Pteridine-2,4(1H,3H)-dione (Standard)
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HY-D0067
7ACC1
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HY-W051513
2-Methylquinazolin-4-ol
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HY-W008343
1,3-Dimethyluracil
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HY-W017519
2-Quinoxalinol
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HY-138545
4-Hydroxy-6-methylcoumarin
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HY-W051513R
2-Methylquinazolin-4-ol (Standard)
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HY-W017519R
2-Quinoxalinol (Standard)
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HY-W008343R
1,3-Dimethyluracil (Standard)
Biological Activity
Silver-coordinated pteridine-2,4 (1H,3H)-dione derivative (6-hydroxyminolumazine) inhibits the proliferation of NB69 and U373-MG cancer cells with IC50 values ranging from 5.25 to 16.37 μM, induces apoptosis in U373-MG cells, and triggers necrosis in NB69 cells[1].
Gold-coordinated Pteridine-2,4 (1H,3H)-dione derivatives (0.5-50 μM) inhibit the proliferation of MCF7, A549, PC3 and LOVO cancer cells, with IC50 values ranging from 0.5 to 50 μM[1].
Pteridine-2,4 (1H,3H)-dione forms a hydrogen-bonded 2:2 cluster with DMF in its monoclinic C2/c crystal structure. Its pteridine ring is nearly planar, exhibits dithione-type stability, and additional intermolecular σ-π interactions are present[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 487-21-8
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Appearance Solid
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Molecular Weight 164.12
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Formula C6H4N4O2
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SMILES
O=C(N1)NC2=NC=CN=C2C1=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (304.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (15.23 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (15.23 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.0931 mL | 30.4655 mL | 60.9310 mL | 152.3276 mL |
| 5 mM | 1.2186 mL | 6.0931 mL | 12.1862 mL | 30.4655 mL | |
| 10 mM | 0.6093 mL | 3.0466 mL | 6.0931 mL | 15.2328 mL | |
| 15 mM | 0.4062 mL | 2.0310 mL | 4.0621 mL | 10.1552 mL | |
| 20 mM | 0.3047 mL | 1.5233 mL | 3.0466 mL | 7.6164 mL | |
| 25 mM | 0.2437 mL | 1.2186 mL | 2.4372 mL | 6.0931 mL | |
| 30 mM | 0.2031 mL | 1.0155 mL | 2.0310 mL | 5.0776 mL | |
| 40 mM | 0.1523 mL | 0.7616 mL | 1.5233 mL | 3.8082 mL | |
| 50 mM | 0.1219 mL | 0.6093 mL | 1.2186 mL | 3.0466 mL | |
| 60 mM | 0.1016 mL | 0.5078 mL | 1.0155 mL | 2.5388 mL | |
| 80 mM | 0.0762 mL | 0.3808 mL | 0.7616 mL | 1.9041 mL | |
| 100 mM | 0.0609 mL | 0.3047 mL | 0.6093 mL | 1.5233 mL |
Pteridine-2,4(1H,3H)-dione Related Classifications
HY-W037619 Related Classifications
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