1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. 2-Methylquinazolin-4-ol

2-Methylquinazolin-4-ol 

Cat. No.: HY-W051513 Purity: >97.0%
Handling Instructions

2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM.

For research use only. We do not sell to patients.

2-Methylquinazolin-4-ol Chemical Structure

2-Methylquinazolin-4-ol Chemical Structure

CAS No. : 1769-24-0

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Description

2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM[1][2].

In Vitro

2-Methylquinazolin-4-ol inhibits ATCase in a concentration-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

2-Methylquinazolin-4-ol (0.2-1 mg; i.g.; for two days) inhibits ATCase in a dosedependent manner in vivo[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[2]
Dosage: 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 1 mg
Administration: Oral gavage, for two days
Result: Showed an inhibitory effect upon ATCase.
Molecular Weight

160.17

Formula

C₉H₈N₂O

CAS No.

1769-24-0

SMILES

O=C1NC(C)=NC2=C1C=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (312.17 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.2434 mL 31.2168 mL 62.4337 mL
5 mM 1.2487 mL 6.2434 mL 12.4867 mL
10 mM 0.6243 mL 3.1217 mL 6.2434 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

2-Methylquinazolin-4-olPARPpoly ADP ribose polymerasepoly(ADP-ribose)synthetaseaspartatetranscarbamylaseATCaseInhibitorinhibitorinhibit

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Product Name:
2-Methylquinazolin-4-ol
Cat. No.:
HY-W051513
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