1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. MC-SN38

MC-SN38 

Cat. No.: HY-136170
Handling Instructions

MC-SN38 is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks.

For research use only. We do not sell to patients.

MC-SN38 Chemical Structure

MC-SN38 Chemical Structure

CAS No. : 1473403-87-0

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Description

MC-SN38 is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks[1][2].

Molecular Weight

585.60

Formula

C₃₂H₃₁N₃O₈

CAS No.

1473403-87-0

SMILES

O=C(CCCCCN(C1=O)C(C=C1)=O)O[[email protected]@](C(C=C(C2=NC3=CC=C4O)N5CC2=C(C3=C4)CC)=C6C5=O)(C(OC6)=O)CC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MC-SN38Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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