Potassium 1H-indol-3-yl sulfate
Based on 1 publication(s) in Google Scholar
Potassium 1H-indol-3-yl sulfate is a metabolite of tryptophan, produced by intestinal microorganisms and combined with sulfate in the liver before entering the circulatory system. Potassium 1H-indol-3-yl sulfate is a potent endogenous agonist of the aryl hydrocarbon receptor (AhR) and a urinary toxin. Potassium 1H-indol-3-yl sulfate can be used for research on kidney diseases.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 2642-37-7
- Formula: C8H6KNO4S
- Molecular Weight:251.30
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-111431
p-Cresyl sulfate
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HY-104026
L-Kynurenine
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HY-100806
Kynurenic acid
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HY-116084
Trimethylamine N-oxide
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HY-N0623
L-Tryptophan
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HY-W013636
2-Ketoglutaric acid
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HY-113099
Indolelactic acid
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HY-W007376
Indole-3-carboxaldehyde
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HY-18569
3-Indoleacetic acid
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HY-W007355
Skatole
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HY-N0122
5-Hydroxytryptophan
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HY-113294
3-Hydroxykynurenine
Publications Citing Use of MedChemExpress (MCE) Potassium 1H-indol-3-yl sulfate
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Potassium 1H-indol-3-yl sulfate (1 nM-100 μM, 6 h) significantly induces the mRNA expression of CYP1A1/1A2/1B1 and UGT1A1/1A6[2].
Potassium 1H-indol-3-yl sulfate (10 nM-1 μM, 1-8 h) regulates immune/inflammatory-related genes (synergistically induces IL6 and inhibits SAA1) in Huh7 cells and primary human liver cells by continuously activating AHR[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh7 cells and primary human liver cells
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Concentration:1, 10 an d 100 μM in Huh7 cells, 1 and 100 nM in primary human hepatocytes
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Incubation Time:6 h
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Result:Significantly induced the mRNA expression of CYP1A1/1A2/1B1 and UGT1A1/1A6, with greater efficacy in primary cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2642-37-7
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Appearance Solid
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Molecular Weight 251.30
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Formula C8H6KNO4S
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Color White to light brown
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SMILES
O=S(OC1=CNC2=C1C=CC=C2)([O-])=O.[K+]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Host Microbe
2025 Oct 8;33(10):1715-1730.e5. PMID: 40961933
Solvent & Solubility
DMSO : 100 mg/mL (397.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (198.97 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.95 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.95 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (99.48 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.9793 mL | 19.8965 mL | 39.7931 mL | 99.4827 mL |
| 5 mM | 0.7959 mL | 3.9793 mL | 7.9586 mL | 19.8965 mL | |
| 10 mM | 0.3979 mL | 1.9897 mL | 3.9793 mL | 9.9483 mL | |
| 15 mM | 0.2653 mL | 1.3264 mL | 2.6529 mL | 6.6322 mL | |
| 20 mM | 0.1990 mL | 0.9948 mL | 1.9897 mL | 4.9741 mL | |
| 25 mM | 0.1592 mL | 0.7959 mL | 1.5917 mL | 3.9793 mL | |
| 30 mM | 0.1326 mL | 0.6632 mL | 1.3264 mL | 3.3161 mL | |
| 40 mM | 0.0995 mL | 0.4974 mL | 0.9948 mL | 2.4871 mL | |
| 50 mM | 0.0796 mL | 0.3979 mL | 0.7959 mL | 1.9897 mL | |
| 60 mM | 0.0663 mL | 0.3316 mL | 0.6632 mL | 1.6580 mL | |
| 80 mM | 0.0497 mL | 0.2487 mL | 0.4974 mL | 1.2435 mL | |
| 100 mM | 0.0398 mL | 0.1990 mL | 0.3979 mL | 0.9948 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Potassium 1H-indol-3-yl sulfate Related Classifications
HY-W011910 Related Classifications
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