2. Others
  3. Isotope-Labeled Compounds
  4. SN-38 glucuronide-13C6

SN-38 glucuronide-13C6  (Synonyms: SN-38G-13C6)

Cat. No.: HY-126373S1 Purity: 96.13%
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SN-38 glucuronide-13C6 is the 13C labeled SN-38 glucuronide (HY-126373). SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer.

For research use only. We do not sell to patients.

SN-38 glucuronide-<sup>13</sup>C<sub>6</sub>

SN-38 glucuronide-13C6 Chemical Structure

Size Price Stock Quantity
100 μg In-stock
1 mg In-stock
5 mg   Get quote  
10 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of SN-38 glucuronide-13C6:

SN-38 glucuronide-13C6 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

SN-38 glucuronide-13C6 is the 13C labeled SN-38 glucuronide (HY-126373)[1]. SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer[2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SN-38 glucuronide-13C6 Related Antibodies
Molecular Weight

574.48

Formula

C2213C6H28N2O11
Unlabeled CAS
Appearance

Solid

Color

Light yellow to yellow

SMILES

CCC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=N[13C]5=[13CH][13CH]=[13C](O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)C(O)=O)[13CH]=[13C]51
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (174.07 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7407 mL 8.7035 mL 17.4070 mL
5 mM 0.3481 mL 1.7407 mL 3.4814 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7407 mL 8.7035 mL 17.4070 mL 43.5176 mL
5 mM 0.3481 mL 1.7407 mL 3.4814 mL 8.7035 mL
10 mM 0.1741 mL 0.8704 mL 1.7407 mL 4.3518 mL
15 mM 0.1160 mL 0.5802 mL 1.1605 mL 2.9012 mL
20 mM 0.0870 mL 0.4352 mL 0.8704 mL 2.1759 mL
25 mM 0.0696 mL 0.3481 mL 0.6963 mL 1.7407 mL
30 mM 0.0580 mL 0.2901 mL 0.5802 mL 1.4506 mL
40 mM 0.0435 mL 0.2176 mL 0.4352 mL 1.0879 mL
50 mM 0.0348 mL 0.1741 mL 0.3481 mL 0.8704 mL
60 mM 0.0290 mL 0.1451 mL 0.2901 mL 0.7253 mL
80 mM 0.0218 mL 0.1088 mL 0.2176 mL 0.5440 mL
100 mM 0.0174 mL 0.0870 mL 0.1741 mL 0.4352 mL
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SN-38 glucuronide-13C6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SN-38 glucuronide-13C6SN-38G-13C6Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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