1. GPCR/G Protein
  2. Endothelin Receptor
  3. IRL 2500

IRL 2500 

Cat. No.: HY-103460 Purity: >99.0%
Handling Instructions

IRL 2500 is a potent Endothelin receptor antagonist. IRL 2500 shows IC50 values of 1.3 and 94 nM for ETB and ETA receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.

For research use only. We do not sell to patients.

IRL 2500 Chemical Structure

IRL 2500 Chemical Structure

CAS No. : 169545-27-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 589 In-stock
Estimated Time of Arrival: December 31
1 mg USD 155 In-stock
Estimated Time of Arrival: December 31
5 mg USD 467 In-stock
Estimated Time of Arrival: December 31
10 mg USD 795 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

IRL 2500 is a potent Endothelin receptor antagonist. IRL 2500 shows IC50 values of 1.3 and 94 nM for ETB and ETA receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo[1].

IC50 & Target[1]

ETB

1.3 nM (IC50)

ETA

94 nM (IC50)

In Vivo

IRL 2500 (intravenous injection;10 mg/kg) inhibits the initial transient decrease in mean arterial pressure (MAP) induced by the ETB-selective agonist IRL 1620 in rats, IRL 2500 also attenuates the IRL 1620-mediated increase in renal vascular resistance (RVR) in the anesthetized rat[1].
IRL 2500 (intravenous injection;10 mg/kg) pre-reatment significantly reduces the initial vasodepressor response to endothelin-1 (ET-1) and IRL 1620, however, it is not alters the secondary and sustained pressor response to these agonists[2].

Molecular Weight

573.68

Formula

C₃₆H₃₅N₃O₄

CAS No.

169545-27-1

SMILES

O=C(O)[[email protected]](CC1=CNC2=CC=CC=C12)NC([[email protected]@H](CC3=CC=C(C4=CC=CC=C4)C=C3)N(C(C5=CC(C)=CC(C)=C5)=O)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References

Purity: >99.0%

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Keywords:

IRL 2500IRL2500IRL-2500Endothelin ReceptorVasodepressorrenalvascularresistanceRVRInhibitorinhibitorinhibit

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Product name:
IRL 2500
Cat. No.:
HY-103460
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